NO control of mitochondrial function in normal and transformed cells

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dc.contributor.authorTengan, Celia H. [UNIFESP]
dc.contributor.authorMoraes, Carlos T.
dc.date.accessioned2019-08-19T11:50:11Z
dc.date.available2019-08-19T11:50:11Z
dc.date.issued2017
dc.description.abstractNitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. (C) 2017 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed São Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, R Pedro de Toledo 781,Setimo Andar, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliationUniv Miami, Miller Sch Med, Dept Neurol & Cell Biol, 1420 NW 9th Ave,Rm 229, Miami, FL 33136 USA
dc.description.affiliationUnifespUniv Fed São Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, R Pedro de Toledo 781,Setimo Andar, BR-04039032 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipNational Institutes of Health (NIH)
dc.description.sponsorshipMuscular Dystrophy Association
dc.description.sponsorshipIDFAPESP: 2007/03134-9
dc.description.sponsorshipIDNIH: 1R01NS079965
dc.description.sponsorshipIDNIH: 1R01AG036871
dc.description.sponsorshipIDNIH: 5R01EY010804
dc.description.sponsorshipIDNIH: 1R21ES025673
dc.description.sponsorshipIDMDA: 294407
dc.format.extent573-581
dc.identifierhttp://dx.doi.org/10.1016/j.bbabio.2017.02.009
dc.identifier.citationBiochimica Et Biophysica Acta-Bioenergetics. Amsterdam, v. 1858, n. 8, p. 573-581, 2017.
dc.identifier.doi10.1016/j.bbabio.2017.02.009
dc.identifier.issn0005-2728
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51487
dc.identifier.wosWOS:000405763800003
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.rightsAcesso aberto
dc.subjectNitric oxideen
dc.subjectNitric oxide synthaseen
dc.subjectMitochondriaen
dc.subjectCanceren
dc.subjectRespiratory chainen
dc.titleNO control of mitochondrial function in normal and transformed cellsen
dc.typeArtigo
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