Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain

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dc.contributor.authorVillares, J.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:58Z
dc.date.available2016-01-24T12:41:58Z
dc.date.issued2007-03-02
dc.description.abstractChronic exposure to Cannabis sativa (marijuana) produced a significant down-regulation of cannabinoid receptor in the postmortem human brain. the significant decrease in maximal binding capacity was not accompanied by changes in the affinity constant. [H-3]SR141716A binding was reduced in the caudate nucleus, putamen and in the accumbens nucleus. A significant decrease of binding sites was seen in the globus pallidus. Also in the ventral tegmental area and substantia nigra pars reticulata quantitative analysis of the density of receptors shows a significant reduction in [H-3]SR141716A binding. in Cannabis sativa user brains, compared with normal brains [H-3]SR141716A binding was reduced only in the hippocampus. the density of cannabinoid receptor 1 mRNA-positive neurons was significantly lower in Cannabis sativa users than in control brains for the caudate nucleus, putamen, accumbens nucleus and hippocampal region (CA1-CA4, areas of Ammon's horn). No hybridization was seen in the mesencephalon and globus pallidus. (c) 2006 IBRO. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, Aging & Neurodegenerat Dis Brain Bank Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, Aging & Neurodegenerat Dis Brain Bank Lab, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent323-334
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2006.11.012
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 145, n. 1, p. 323-334, 2007.
dc.identifier.doi10.1016/j.neuroscience.2006.11.012
dc.identifier.issn0306-4522
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29588
dc.identifier.wosWOS:000244489100031
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCannabis sativaen
dc.subjectCB1 receptor bindingen
dc.subjectchronic drug exposureen
dc.subjectpostmortem human brainen
dc.subjectmRNA CB1 expressionen
dc.subjectpsychostimulantsen
dc.titleChronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brainen
dc.typeArtigo
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