Effects of pre- or post-training entorhinal cortex AP5 injection on fear conditioning

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dc.contributor.authorSchenberg, E. E.
dc.contributor.authorSoares, JCK
dc.contributor.authorOliveira, MGM
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:38:10Z
dc.date.available2016-01-24T12:38:10Z
dc.date.issued2005-11-15
dc.description.abstractFear conditioning is one of the most studied paradigms to assess the neural basis of emotional memory. the circuitry involves NNMA receptor activation in the amygdala and, in the case of contextual conditioning, in the hippocampus. Entorhinal cortex is one of the major input/output structures to the hippocampus and also projects to the amygdala, both through glutamatergic transmission. Other learning tasks involving hippocampus and amygdala, such as inhibitory avoidance, require entorhinal cortex during acquisition and consolidation. However, the involvement of NMDA receptors mediated transmission in entorhinal cortex in fear conditioning acquisition and consolidation is not clear. To investigate that issue, rats were trained in fear conditioning to both contextual and tone conditioned stimulus. Immediately before, immediately, 30 or 90 min after training they received NMDA antagonist AP5 or saline injections bilaterally in the entorhinal cortex (AP-6.8 mm, L +/- 5.0 mm DV-6.8 mm). Contextual fear conditioning was measured 24 h after training, and tone fear conditioning 48 h after training. AP5 injections selectively impaired contextual fear conditioning only when injected pre-training. Post-training injections had no effect. These findings suggest that entorhinal cortex NMDA receptors are necessary for acquisition, but not for consolidation, of contextual fear conditioning. On the other hand, both acquisition and consolidation of tone fear conditioning seem to be independent of NMDA receptors in the entorhinal cortex. (c) 2005 Elsevier Inc. All fights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent508-515
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2005.08.032
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 86, n. 4, p. 508-515, 2005.
dc.identifier.doi10.1016/j.physbeh.2005.08.032
dc.identifier.issn0031-9384
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28550
dc.identifier.wosWOS:000233479800012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhysiology & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectacquisitionen
dc.subjectAP5en
dc.subjectconsolidationen
dc.subjectentorhinal cortexen
dc.subjectfear conditioningen
dc.subjectmemoryen
dc.subjectNMDAen
dc.titleEffects of pre- or post-training entorhinal cortex AP5 injection on fear conditioningen
dc.typeinfo:eu-repo/semantics/article
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