Multicenter study of wound healing in neurofibromatosis and neurofibroma

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dc.contributor.authorMiyawaki, Takeshi
dc.contributor.authorBillings, Brian
dc.contributor.authorHar-Shai, Yaron
dc.contributor.authorAgbenorku, Pius
dc.contributor.authorKokuba, Elisa [UNIFESP]
dc.contributor.authorMoreira-Gonzalez, Andrea [UNIFESP]
dc.contributor.authorTsukuno, Mari
dc.contributor.authorKurihara, Kunihiro
dc.contributor.authorJackson, Ian T.
dc.contributor.institutionProvidence Hosp
dc.contributor.institutionJikei Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionLady Davis Carmel Med Ctr
dc.date.accessioned2018-06-15T17:58:41Z
dc.date.available2018-06-15T17:58:41Z
dc.date.issued2007-09-01
dc.description.abstractBased on clinical experience, the senior author has become convinced that wounds produced to correct the deformities of patients with neurofibromatosis (NF-1) have produced remarkably good scars, the interesting feature being that progression to keloid or hypertrophic scar is rare. The other point noted was that this situation did not change, no matter the patient's race or skin color. There have been few reports describing or discussing this hypothesis. The purpose of this study was to investigate whether wounds produced in the patients with NF-1 produce keloid or hypertrophic scars. The patients with solitary neurofibroma were also included in this study; these were compared with the NF-1 group. This was conducted as a multicenter study. Patients with neurofibromatosis/solitary neurofibroma, who were operated on from 1990 to 2000, were evaluated by reviewing their medical charts and photographs retrospectively. The patients were treated in centers from five different countries. The analysis was undertaken based on the following points: 1) age and sex at surgery; 2) race of the patients; 3) past and family histories of hypertrophic scar and keloid; 4) surgical site(s); 5) diagnosis, NF1 or solitary neurofibroma; 6) surgical complications; 7) number of reoperations to manage the complications; 8) adjuvant therapy for the tumor; 9) depth of the tumors; and 10) incidence of malignant degeneration. A total of 101 cases with neurofibromatosis or solitary neurofibroma was analyzed. The age at surgery ranged from 1 year 6 months to 74 years; sex ratio was 47 males and 54 females. The racial distribution of the patients was 13 white, 13 black, 3 Hispanic, and 58 Asian. There was no past or family history of hypertrophic scar or keloid. The surgical sites were head and neck in 70 cases, trunk in 20 cases, upper extremities in 22 cases, and lower extremities in 20 cases. The clinical diagnosis was NF-1 in W cases, solitary neurofibroma in 35 cases, plexiform neurofibroma in four cases, and no distinct clinical diagnosis in five cases. There were no other types of neurofibiomatosis. Hematoma and white wide scar were the main postoperative complications found in six cases of NF-1. Infection was also noted in four cases. However, no patient developed hypertrophic scar or keloid in the neurofibromatosis group, whereas two cases showed hypertrophic scar in the solitary neurofibroma group. The outcome showed that the patients with NF-1 and plexiform neurofibroma, no matter the racial group, produce good scars without keloid or hypertrophic changes, whereas solitary neurofibroma has a potential to cause hypertrophic scar.en
dc.description.affiliationProvidence Hosp, Inst Craniofacial & Reconstruct Surg, Southfield, MI 48037 USA
dc.description.affiliationJikei Univ, Sch Med, Dept Plast & Reconstruct Surg, Tokyo, Japan
dc.description.affiliationUniv Fed Sao Paulo, Dept Plast Surg, Sao Paulo, Brazil
dc.description.affiliationLady Davis Carmel Med Ctr, Haifa, Israel
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Plast Surg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1008-1011
dc.identifierhttp://doi.org/10.1097/scs.0b013e31811f3587
dc.identifier.citationJournal Of Craniofacial Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 5, p. 1008-1011, 2007.
dc.identifier.doi10.1097/scs.0b013e31811f3587
dc.identifier.issn1049-2275
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44338
dc.identifier.wosWOS:000249894600004
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Craniofacial Surgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectneurofibromatosisen
dc.subjectneurofibromaen
dc.subjectNF-1en
dc.subjectvon Recklinghausen's diseaseen
dc.subjectwound healingen
dc.subjecthypertrophic scaren
dc.subjectkeloiden
dc.titleMulticenter study of wound healing in neurofibromatosis and neurofibromaen
dc.typeinfo:eu-repo/semantics/article
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