Cognitive Enhancement Induced by Anodal tDCS Drives Circuit-Specific Cortical Plasticity

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dc.citation.issue4
dc.citation.volumev. 28
dc.contributor.authorPisoni, Alberto
dc.contributor.authorMattavelli, Giulia
dc.contributor.authorPapagno, Costanza
dc.contributor.authorRosanova, Mario
dc.contributor.authorCasali, Adenauer G. [UNIFESP]
dc.contributor.authorLauro, Leonor J. Romero
dc.coverageCary
dc.date.accessioned2020-07-20T16:31:10Z
dc.date.available2020-07-20T16:31:10Z
dc.date.issued2018
dc.description.abstractIncreasing evidence shows that anodal transcranial direct current stimulation (tDCS) enhances cognitive performance in healthy and clinical population. Such facilitation is supposed to be linked to plastic changes at relevant cortical sites. However, direct electrophysiological evidence for this causal relationship is still missing. Here, we show that cognitive enhancement occurring in healthy human subjects during anodal tDCS is affected by ongoing brain activity, increasing cortical excitability of task-related brain networks only, as directly measured by Transcranial Magnetic Stimulation combined with electroencephalography (TMS-EEG). Specifically, TMS-EEG recordings were performed before and after anodal tDCS coupled with a verbal fluency task. To control for effects of tDCS protocol and TMS target location, 3 conditions were assessed: anodal/sham tDCS with TMS over left premotor cortex, anodal tDCS with TMS over left posterior parietal cortex. Modulation of cortical excitability occurred only at left Brodmann's areas 6, 44, and 45, a key network for language production, after anodal tDCS and TMS over the premotor cortex, and was positively correlated to the degree of cognitive enhancement. Our results suggest that anodal tDCS specifically affects task-related functional networks active while delivering stimulation, and this boost of specific cortical circuits is correlated to the observed cognitive enhancement.en
dc.description.affiliationUniv Milano Bicocca, Dept Psychol, I-20126 Milan, Italy
dc.description.affiliationMilan Ctr Neurosci, NeuroMi, I-20126 Milan, Italy
dc.description.affiliationUniv Milan, Dept Clin Sci Luigi Sacco, I-20157 Milan, Italy
dc.description.affiliationFERB Onlus, Fdn Europea Ric Biomed, I-20063 Milan, Milano, Italy
dc.description.affiliationUniv Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv Trento, CeRiN Ctr Riabilitaz Neurocognit, I-38068 Rovereto, Italy
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-20T16:31:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.description.sourceWeb of Science
dc.format.extent1132-1140
dc.identifierhttp://dx.doi.org/10.1093/cercor/bhx021
dc.identifier.citationCerebral Cortex. Cary, v. 28, n. 4, p. 1132-1140, 2018.
dc.identifier.doi10.1093/cercor/bhx021
dc.identifier.issn1047-3211
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55755
dc.identifier.wosWOS:000428877200004
dc.language.isoeng
dc.publisherOxford Univ Press Inc
dc.relation.ispartofCerebral Cortex
dc.rightsAcesso restrito
dc.subjectanodal tDCSen
dc.subjectcortical excitabilityen
dc.subjectTMS-EEGen
dc.subjectverbal fluencyen
dc.titleCognitive Enhancement Induced by Anodal tDCS Drives Circuit-Specific Cortical Plasticityen
dc.typeArtigo
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