Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis

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dc.citation.volume128
dc.contributor.authorJardim, Anaclara Prada [UNIFESP]
dc.contributor.authorCorso, Jeana Torres [UNIFESP]
dc.contributor.authorGarcia, Maria Teresa Fernandes Castilho [UNIFESP]
dc.contributor.authorGaca, Larissa Botelho [UNIFESP]
dc.contributor.authorComper, Sandra Mara [UNIFESP]
dc.contributor.authorPenteado Lancellotti, Carmen Lucia
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorScorza, Carla Alessandra [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-31T12:47:08Z
dc.date.available2020-07-31T12:47:08Z
dc.date.issued2016
dc.description.abstractPurpose: To correlate hippocampal volumes obtained from brain structural imaging with histopathological patterns of hippocampal sclerosis (HS), in order to predict surgical outcome. Methods: Patients with mesial temporal lobe epilepsy (MTLE) with HS were selected. Clinical data were assessed pre-operatively and surgical outcome in the first year post surgery. One block of mid hippocampal body was selected for HS classification according to ILAE criteria. NeuN-immunoreactive cell bodies were counted within hippocampal subfields, in four randomly visual fields, and cell densities were transformed into z-score values. FreeSurfer processing of 1.5 T brain structural images was used for subcortical and cortical volumetric estimation of the ipsilateral hippocampus. Univariate analysis of variance and Pearson's correlation test were applied for statistical analyses. Results: Sixty-two cases (31 female, 32 right HS) were included. ILAE type 1 HS was identified in 48 patients, type 2 in eight, type 3 in two, and four had no-HS. Better results regarding seizure control, i.e. ILAE 1, were achieved by patients with type 1 HS (58.3%). Patients with types 1 and 2 had smaller hippocampal volumes compared to those with no-HS (p<0.001 and p=0.004, respectively). Positive correlation was encountered between hippocampal volumes and CA1, CA3, CA4, and total estimated neuronal densities. CA2 was the only sector which did not correlate its neuronal density with hippocampal volume (p = 0.390). Conclusion: This is the first study correlating hippocampal volume on MRI submitted to FreeSurfer processing with ILAE patterns of HS and neuronal loss within each hippocampal subfield, a fundamental finding to anticipate surgical prognosis for patients with drug-resistant MTLE and HS. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Clin Neurol Sect, Rua Pedro Toledo 650,1 Andar, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationFac Ciencias Med Santa Casa Sao Paulo, Dept Pathol Sci, Rua Dr Cesareo Mottak Jr,61 Vila Buarque, BR-01221020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Neurosurg Sect, Dept Neurol & Neurosurg, Rua Napoleao Barros 715,6 Andar Vila Clementino, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Diagnost Imaging Sect, Dept Diagnost Imaging, Rua Napoleao Barros 800 Vila Clementino, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Neurosci Sect, Dept Neurol & Neurosurg, Rua Pedro Toledo 669,2 Andar Vila Clementino, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespClinical Neurology Sector, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 650 – Vila Clementino, CEP 04039-002, São Paulo, SP, Brazil
dc.description.affiliationUnifespNeurosurgery Sector, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 715, 6° andar – Vila Clementino, CEP 04024-002, São Paulo, SP, Brazil
dc.description.affiliationUnifespDiagnostic Imaging Sector, Department of Diagnostic Imaging, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 800 – Vila Clementino, CEP 04024-002, São Paulo, SP, Brazil
dc.description.affiliationUnifespNeuroscience Sector, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 669, 2° andar – Vila Clementino, CEP 04039-032, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent169-175
dc.identifierhttp://dx.doi.org/10.1016/j.eplepsyres.2016.10.014
dc.identifier.citationEpilepsy Research. Amsterdam, v. 128, p. 169-175, 2016.
dc.identifier.doi10.1016/j.eplepsyres.2016.10.014
dc.identifier.issn0920-1211
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56614
dc.identifier.wosWOS:000390742500023
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofEpilepsy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMesial temporal lobe epilepsyen
dc.subjectHippocampal sclerosisen
dc.subjectHippocampal atrophyen
dc.subjectSurgical outcomeen
dc.subjectFreeSurfer analysisen
dc.titleHippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosisen
dc.typeinfo:eu-repo/semantics/article
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