Trabeculectomy in pseudophakic patients: postoperative 5-fluorouracil versus intraoperative mitomycin C antiproliferative therapy

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dc.contributor.authorPrata Junior, João Antonio [UNIFESP]
dc.contributor.authorMinckler, Donald S.
dc.contributor.authorBaerveldt, George
dc.contributor.authorLee, Paul P.
dc.contributor.authorLabree, Laurie
dc.contributor.authorHeuer, Dale K.
dc.contributor.institutionUNIV SO CALIF
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:23:32Z
dc.date.available2018-06-18T11:23:32Z
dc.date.issued1995-01-01
dc.description.abstractTrabeculectomy outcome in pseudophakic glaucoma patients treated with mitomycin C (MMC) or 5-fluorouracil (5-FU) was analyzed retrospectively in 46 cases (46 eyes). Thirty patients received intraoperative MMC; 16, 5-FU. There were no significant differences between the two groups in terms of preoperative data (demographics, number of previous filtering procedures, visual acuity, and intraocular pressure [IOP]). After a mean follow up of 13.4 +/- 8.1 and 11.5 +/- 5.8 months for the 5-FU and MMC groups, respectively, 12 5-FU eyes (75%) and 21 MMC eyes (70%) were deemed at least qualified successes (IOP less-than-or-equal-to 21 mm Hg with or without antiglaucoma medications). Six (37.5%) of the 5-FU eyes and 13 (43.3%) of the MMC eyes were complete successes (IOP less-than-or-equal-to 21 mm Hg without antiglaucoma medications). There were no significant differences between the two groups in terms of duration of follow up, number of qualified successes, and number of complete successes (P = .35, .9, and .7, respectively). Nor were there any significant differences in the mean final IOPs and visual acuities. Excluding transient corneal effects associated with 5-FU therapy, there were no significant differences in the frequency of postoperative complications.These results suggest that 5-FU and MMC antiproliferative therapy are associated with similar short-term success rates and postoperative complications.en
dc.description.affiliationUNIV SO CALIF,SCH MED,DOHENY EYE INST,DEPT OPHTHALMOL,LOS ANGELES,CA 90033
dc.description.affiliationESCOLA PAULISTA MED,DEPT OPHTHALMOL,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT OPHTHALMOL,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent73-77
dc.identifierhttp://dx.doi.org/10.3928/1542-8877-19950101-16
dc.identifier.citationOphthalmic Surgery And Lasers. Thorofare: Slack Inc, v. 26, n. 1, p. 73-77, 1995.
dc.identifier.doi10.3928/1542-8877-19950101-16
dc.identifier.issn0022-023X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45069
dc.identifier.wosWOS:A1995QG38800014
dc.language.isoeng
dc.publisherSlack Inc
dc.relation.ispartofOphthalmic Surgery And Lasers
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleTrabeculectomy in pseudophakic patients: postoperative 5-fluorouracil versus intraoperative mitomycin C antiproliferative therapyen
dc.typeinfo:eu-repo/semantics/article
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