Dimensional correlates of poor insight in obsessive-compulsive disorder

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dc.contributor.authorJakubovski, Ewgeni
dc.contributor.authorPittenger, Christopher
dc.contributor.authorTorres, Albina Rodrigues
dc.contributor.authorFontenelle, Leonardo Franklin
dc.contributor.authorRosario, Maria Conceicao do [UNIFESP]
dc.contributor.authorFerroo, Ygor Arzeno
dc.contributor.authorMathis, Maria Alice de
dc.contributor.authorMiguel, Euripedes Constantino
dc.contributor.authorBloch, Michael H.
dc.contributor.institutionYale Univ
dc.contributor.institutionUniv Heidelberg
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Ciencias Saude Porto Alegre
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:17:06Z
dc.date.available2016-01-24T14:17:06Z
dc.date.issued2011-08-15
dc.description.abstractBackground: Cross-sectional studies have associated poor insight in patients with obsessive-compulsive disorder (OCD) with increased OCD symptom severity, earlier age of onset, comorbid depression, and treatment response. the goal of this current study was to examine the relationship between dimensions of OCD symptomatology and insight in a large clinical cohort of Brazilian patients with OCD. We hypothesized that poor insight would be associated with total symptom severity as well as with hoarding symptoms severity, specifically.Methods: 824 outpatients underwent a detailed clinical assessment for OCD, including the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), the Brown Assessment of Beliefs Scale (BABS), a socio-demographic questionnaire, and the Structured Clinical Interview for axis I DSM-IV disorders (SCID-P). Tobit regression models were used to examine the association between level of insight and clinical variables of interest.Results: Increased severity of current and worst-ever hoarding symptoms and higher rate of unemployment were associated with poor insight in OCD after controlling for current OCD severity, age and gender. Poor insight was also correlated with increased severity of current OCD symptoms.Conclusion: Hoarding and overall OCD severity were significantly but weakly associated with level of insight in OCD patients. Further studies should examine insight as a moderator and mediator of treatment response in OCD in both behavioral therapy and pharmacological trials. Behavioral techniques aimed at enhancing insight may be potentially beneficial in OCD, especially among patients with hoarding. (C) 2011 Published by Elsevier Inc.en
dc.description.affiliationYale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
dc.description.affiliationUniv Heidelberg, Dept Psychol, D-6900 Heidelberg, Germany
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Psychiat, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationUniv Fed Ciencias Saude Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Psychiat, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psiquiatria, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Mental Health
dc.description.sponsorshipYale Child Study Center
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipAACAP/Eli Lilly
dc.description.sponsorshipTrichotillomania Learning Center
dc.description.sponsorshipNARSAD
dc.description.sponsorshipDoris Duke Charitable Foundation
dc.description.sponsorshipNational Center for Research Resources, a component of the National Institutes of Health
dc.description.sponsorshipNIH roadmap for Medical Research
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDNational Institutes of Health: 1K23MH091240-01
dc.description.sponsorshipIDNational Institutes of Health: K08 MH081190
dc.description.sponsorshipIDNational Center for Research Resources, a component of the National Institutes of Health: UL1 RR024139
dc.description.sponsorshipIDFAPESP: 08/5759
dc.format.extent1677-1681
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2011.05.012
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 7, p. 1677-1681, 2011.
dc.identifier.doi10.1016/j.pnpbp.2011.05.012
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33959
dc.identifier.wosWOS:000294941800021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectHoardingen
dc.subjectInsighten
dc.subjectObsessive-compulsive disorderen
dc.subjectSymptom dimensionen
dc.titleDimensional correlates of poor insight in obsessive-compulsive disorderen
dc.typeinfo:eu-repo/semantics/article
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