Single agent vinorelbine in pediatric patients with progressive optic pathway glioma

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dc.contributor.authorCappellano, Andrea Maria [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.authorSilva, Nasjla Saba da [UNIFESP]
dc.contributor.authorSilva, Frederico Adolfo [UNIFESP]
dc.contributor.authorPaiva, Priscila Mendes [UNIFESP]
dc.contributor.authorCavalheiro, Sergio [UNIFESP]
dc.contributor.authorBouffet, Eric
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Toronto
dc.date.accessioned2016-01-24T14:39:48Z
dc.date.available2016-01-24T14:39:48Z
dc.date.issued2015-01-01
dc.description.abstractThe management of progressive unresectable low-grade glioma remains controversial. Treatment options have included radiotherapy, and more recently chemotherapy, usually following an initial period of observation. Within this context, we evaluated vinorelbine, a semisynthetic vinca alkaloid that has shown evidence of activity against glioma. From July 2007 an institutional protocol with vinorelbine (30 mg/m 2 days 0, 8, 22) for a total of 18 cycles, has been conducted at IOP/GRAACC/UNIFESP for children with optic pathway glioma (OPG). the main objectives were clinical and radiological response, as well as toxicity profile. Twenty-three patients with progressive OPG with a mean age of 69 months (4-179) were enrolled. Three patients had a diagnosis of neurofibromatosis type 1. Twenty-two patients were assessable for response with an overall objective response rate of 63%, with eight patients showing stable disease. the most important toxicity was hematologic (grade III/IV neutropenia) observed in four patients. Gastrointestinal toxicity (grade I/II vomiting) was observed in seven patients and only 1 patient showed grade I peripheral neuropathy. the median progression-free survival (PFS) was 33 months (6.9-69) with a 3 and 5 year PFS of 64 +/- 19 and 37 +/- 20%, respectively, for an overall 3 and 5 year-survival of 95 +/- 10%. This study suggests that vinorelbine may be an interesting option for pediatric low-grade gliomas, showing low toxicity profile and providing a good quality of life for patients with such chronic disease.en
dc.description.affiliationUniversidade Federal de São Paulo, IOP GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, IOP GRAACC, Dept Radiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, IOP GRAACC, Dept Nursing, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, IOP GRAACC, Neurosurg Dept, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, IOP GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, IOP GRAACC, Dept Radiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, IOP GRAACC, Dept Nursing, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, IOP GRAACC, Neurosurg Dept, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent405-412
dc.identifierhttp://dx.doi.org/10.1007/s11060-014-1652-6
dc.identifier.citationJournal of Neuro-oncology. New York: Springer, v. 121, n. 2, p. 405-412, 2015.
dc.identifier.doi10.1007/s11060-014-1652-6
dc.identifier.issn0167-594X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38576
dc.identifier.wosWOS:000349010200021
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Neuro-oncology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectProgressive unresectable low-grade gliomaen
dc.subjectOptic pathway gliomaen
dc.subjectVinca alkaloiden
dc.subjectVinorelbineen
dc.titleSingle agent vinorelbine in pediatric patients with progressive optic pathway gliomaen
dc.typeinfo:eu-repo/semantics/article
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