Morphometric MRI features are associated with surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis

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dc.citation.volume132
dc.contributor.authorFernandes Castilho Garcia, Maria Teresa [UNIFESP]
dc.contributor.authorGaca, Larissa Botelho [UNIFESP]
dc.contributor.authorSandim, Gabriel Barbosa [UNIFESP]
dc.contributor.authorAssuncao Leme, Idaiane Batista
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorSato, Joao Ricardo
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-13T11:53:23Z
dc.date.available2020-07-13T11:53:23Z
dc.date.issued2017
dc.description.abstractPurpose: Corticoamygdalohippocampectomy (CAH) improves seizure control, quality of life, and decreases mortality for refractory mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). One-third of patients continue having seizures, and it is pivotal to determine structural abnormalities that might influence the postoperative outcome. Studies indicate that nonhippocampal regions may play a role in the epileptogenic network in MTLE-HS and could generate seizures postoperatively. The aim of this study is to analyze areas of atrophy, not always detected on routine MRI, comparing patients who became seizure free (SF) with those non seizure free (NSF) after CAH, in an attempt to establish possible predictors of surgical outcome. Methods:105 patients with refractory MTLE-HS submitted to CAH (59 left MTLEen
dc.description.abstract46 males) and 47 controls were enrolled. FreeSurfer was performed for cortical thickness and volume estimation comparing patients to controls and SF versus NSF patients. The final sample after post processing procedures resulted in 99 patients. Results: Cortical thickness analyses showed reductions in left insula in NSF patients compared to those SF. Significant volume reductions in SF patients were present in bilateral thalami, hippocampi and pars opercularis, left parahippocampal gyrus and right temporal pole. In NSF patients reductions were present bilaterally in thalami, hippocampi, entorhinal cortices, superior frontal and supramarginal gyrien
dc.description.abstracton the left: superior and middle temporal gyri, temporal pole, parahippocampal gyrus, pars opercularis and middle frontal gyrusen
dc.description.abstractand on the right: precentral, superior, middle and inferior temporal gyri. Comparison between SF and NSF patients showed ipsilateral gray matter reductions in the right entorhinal cortex (p = 0.003) and contralateral parahippocampal gyrus (p = 0.05) in right MTLE-HS. Patients NSF had a longer duration of epilepsy than those SF (p = 0.028). Conclusion: NSF patients exhibited more extensive areas of atrophy than SF ones. As entorhinal cortex and parahippocampal gyrus are reduced in NSF patients compared to those SF these structures might be implicated in the network responsible for the maintenance of postoperative seizures. Duration of epilepsy is a predictor of seizure outcome. (C) 2017 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Unidade Pesquisa & Tratamento Epilepsias, Dept Neurol & Neurosurg, Rua Pedro Toledo 650, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Diagnost Imaging, Rua Napoleao Barros 800, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv ABC, Dept Math Computat & Cognit, Ave Estados 5001, BR-09210580 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Unidade Pesquisa & Tratamento Epilepsias, Dept Neurol & Neurosurg, Rua Pedro Toledo 650, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Diagnost Imaging, Rua Napoleao Barros 800, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038000 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent78-83
dc.identifierhttp://dx.doi.org/10.1016/j.eplepsyres.2017.02.022
dc.identifier.citationEpilepsy Research. Amsterdam, v. 132, p. 78-83, 2017.
dc.identifier.doi10.1016/j.eplepsyres.2017.02.022
dc.identifier.issn0920-1211
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54585
dc.identifier.wosWOS:000401682300012
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofEpilepsy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMesial temporal lobe epilepsyen
dc.subjectHippocampal sclerosisen
dc.subjectMRI morphometric analysesen
dc.subjectSurgical outcomeen
dc.titleMorphometric MRI features are associated with surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosisen
dc.typeinfo:eu-repo/semantics/article
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