Tryptophan overloading activates brain regions involved with cognition, mood and anxiety

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dc.citation.issue1
dc.citation.volume89
dc.contributor.authorSilva, Luana Cristina de Almeida [UNIFESP]
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.authorAndrade, José Simões de [UNIFESP]
dc.contributor.authorSouza, Melyssa Alves [UNIFESP]
dc.contributor.authorCéspedes, Isabel Cristina [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.coverageRio Janeiro
dc.date.accessioned2020-07-17T14:02:44Z
dc.date.available2020-07-17T14:02:44Z
dc.date.issued2017
dc.description.abstractTryptophan is the only precursor of serotonin and mediates serotonergic activity in the brain. Previous studies have shown that the administration of tryptophan or tryptophan depletion significantly alters cognition, mood and anxiety. Nevertheless, the neurobiological alterations that follow these changes have not yet been fully investigated. The aim of this study was to verify the effects of a tryptophan-enriched diet on immunoreactivity to Fos-protein in the rat brain. Sixteen male Wistar rats were distributed into two groups that either received standard chow diet or a tryptophan-enriched diet for a period of thirty days. On the morning of the 31st day, animals were euthanized and subsequently analyzed for Fos-immunoreactivity (Fos-ir) in the dorsal and median raphe nuclei and in regions that receive serotonin innervation from these two brain areas. Treatment with a tryptophan-enriched diet increased Fos-ir in the prefrontal cortex, nucleus accumbens, paraventricular hypothalamus, arcuate and ventromedial hypothalamus, dorsolateral and dorsomedial periaqueductal grey and dorsal and median raphe nucleus. These observations suggest that the physiological and behavioral alterations that follow the administration of tryptophan are associated with the activation of brain regions that regulate cognition and mood/anxiety-related responses.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, Rua Napoleao Barros 925,3 Andar, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Rua Silva Jardim 136,3 Andar, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, Rua Napoleao Barros 925,3 Andar, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, Rua Silva Jardim 136,3 Andar, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.format.extent273-283
dc.identifierhttps://dx.doi.org/10.1590/0001-3765201720160177
dc.identifier.citationAnais da Academia Brasileira de Ciências. Rio Janeiro, v. 89, n. 1, p. 273-283, 2017.
dc.identifier.doi10.1590/0001-3765201720160177
dc.identifier.fileWOS000399760100024.pdf
dc.identifier.issn0001-3765
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54976
dc.identifier.wosWOS:000399760100024
dc.language.isoeng
dc.publisherAcad Brasileira de Ciências
dc.relation.ispartofAnais da Academia Brasileira de Ciências
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFos proteinen
dc.subjectImmunoreactivityen
dc.subjectSerotoninen
dc.subjectTryptophanen
dc.titleTryptophan overloading activates brain regions involved with cognition, mood and anxietyen
dc.typeinfo:eu-repo/semantics/article
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