Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection

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dc.contributor.authorSouza e Silva, Ivonete Sandra de [UNIFESP]
dc.contributor.authorFerraz, MLCG
dc.contributor.authorPerez, R. M.
dc.contributor.authorLanzoni, V. P.
dc.contributor.authorFigueiredo, V. M.
dc.contributor.authorSilva, AEB
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:02Z
dc.date.available2016-01-24T12:37:02Z
dc.date.issued2004-03-01
dc.description.abstractBackground: Increased serum gamma-glutamyl transferase (GGT) levels are frequently observed in chronic hepatitis C virus (HCV) infection. However, the significance of this finding remains unclear. the purpose of the present paper was to assess the relationship between GGT levels and clinical, biochemical and histological features in chronic HCV-infected carriers.Methods: Patients with a liver biopsy presenting anti-HCV and HCV-RNA were evaluated. Age, gender, risk factors of transmission, serum alanine aminotransferase (ALT), GGT and alkaline phosphatase (ALP) levels and histological features were assessed in all. Data were analyzed statistically by the chi(2) test and multivariate logistic regression analysis.Results: Among 201 patients studied, elevated GGT levels and bile duct damage were observed in 48% and 35% of them, respectively. No association was seen between GGT level and bile duct damage or between GGT level and hepatic steatosis. Inititally, age >40 years (P=0.007), elevated ALT (P=0.01), grading of inflammatory activity (P=0.004) and staging of fibrosis (P<0.001) were found to be associated with elevated GGT levels. After multivariate regression analysis, histology grading 3 and 4 inflammation activity (P=0.01) and staging 3 and 4 fibrosis (P=0.01) remained independently associated with elevated GGT level.Conclusions: A significant number of patients with chronic HCV infection had elevated serum GGT levels. Furthermore, this enzyme seemed to be useful as an indirect marker of more advanced liver disease in chronic hepatitis C. (C) 2004 Blackwell Publishing Asia Pty Ltd.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, Escola Paulista Med São Paulo, Dept Gastroenterol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, Escola Paulista Med São Paulo, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, Escola Paulista Med São Paulo, Dept Gastroenterol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, Escola Paulista Med São Paulo, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent314-318
dc.identifierhttp://dx.doi.org/10.1111/j.1440-1746.2003.03256.x
dc.identifier.citationJournal of Gastroenterology and Hepatology. Carlton: Blackwell Publishing Asia, v. 19, n. 3, p. 314-318, 2004.
dc.identifier.doi10.1111/j.1440-1746.2003.03256.x
dc.identifier.issn0815-9319
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27664
dc.identifier.wosWOS:000188506000011
dc.language.isoeng
dc.publisherBlackwell Publishing Asia
dc.relation.ispartofJournal of Gastroenterology and Hepatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectchronic infectionen
dc.subjectcirrhosisen
dc.subjectgamma-glutamyl transferaseen
dc.subjecthepatitis Cen
dc.subjectliver diseaseen
dc.titleRole of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infectionen
dc.typeinfo:eu-repo/semantics/article
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