Follicular helper t cell in immunity and autoimmunity

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dc.contributor.authorMesquita, D., Jr. [UNIFESP]
dc.contributor.authorCruvinel, W. M. [UNIFESP]
dc.contributor.authorResende, L. S.
dc.contributor.authorMesquita, F. V. [UNIFESP]
dc.contributor.authorSilva, N. P. [UNIFESP]
dc.contributor.authorCamara, N. O. S.
dc.contributor.authorAndrade, L. E. C. [UNIFESP]
dc.date.accessioned2019-01-21T10:29:57Z
dc.date.available2019-01-21T10:29:57Z
dc.date.issued2016
dc.description.abstractThe traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh). These new subsets have many features in common, such as the ability to produce IL-21 and to express the IL-23 receptor (IL23R), the inducible costimulatory molecule ICOS, and the transcription factor c-Maf, all of them essential for expansion and establishment of the final pool of both subsets. Tfh cells differ from Th17 by their ability to home to B cell areas in secondary lymphoid tissue through interactions mediated by the chemokine receptor CXCR5 and its ligand CXCL13. These CXCR5(+) CD4(+) T cells are considered an effector T cell type specialized in B cell help, with a transcriptional profile distinct from Th1 and Th2 cells. The role of Tfh cells and its primary product, IL-21, on B-cell activation and differentiation is essential for humoral immunity against infectious agents. However, when deregulated, Tfh cells could represent an important mechanism contributing to exacerbated humoral response and autoantibody production in autoimmune diseases. This review highlights the importance of Tfh cells by focusing on their biology and differentiation processes in the context of normal immune response to infectious microorganisms and their role in the pathogenesis of autoimmune diseases.en
dc.description.affiliationDivisão de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationDivisão de Farmacologia, Instituto de Ciências Biológicas, Universidade de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationDivisão de Imunologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationEscola de Ciências Médicas, Farmacêuticas e Biomédicas, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil
dc.description.affiliationUnifespDivisão de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.sourceWeb of Science
dc.format.extente5209
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20165209
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao paulo, v. 49, n. 5, p. e5209, 2016.
dc.identifier.doi10.1590/1414-431X20165209
dc.identifier.fileS0100-879X2016000500302.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2016000500302
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49499
dc.identifier.wosWOS:000376684000007
dc.language.isoeng
dc.publisherAssoc bras divulg cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutoimmune Diseasesen
dc.subjectTfhen
dc.subjectLymphoid Tissueen
dc.subjectHumoral ImmunitySystemic-Lupus-Erythematosusen
dc.subjectB-Cellen
dc.subjectMyasthenia-Gravisen
dc.subjectRheumatoid-Arthritisen
dc.subjectInducible Costimulatoren
dc.subjectCutting Edgeen
dc.subjectPlasma-Cellsen
dc.subjectInterleukin-21 Receptoren
dc.subjectSjogrens-Syndromeen
dc.subjectHumoral Immunityen
dc.titleFollicular helper t cell in immunity and autoimmunityen
dc.typeinfo:eu-repo/semantics/review
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