VEGF 936C/T Polymorphism and Gestational Trophoblastic Neoplasia

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dc.contributor.authorSun, Sue Yazaki [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.contributor.authorSignorini Filho, Roney Cesar [UNIFESP]
dc.contributor.authorRocha, Claudia Lima [UNIFESP]
dc.contributor.authorSouza, Renato Teixeira [UNIFESP]
dc.contributor.authorMoron, Antonio Fernandes [UNIFESP]
dc.date.accessioned2019-07-22T15:46:47Z
dc.date.available2019-07-22T15:46:47Z
dc.date.issued2016
dc.description.abstractOBJECTIVE: To evaluate the relationship between the 936C/T polymorphism of VEGF and the occurrence of gestational trophoblastic neoplasia (GTN). STUDY DESIGN: A retrospective study that included 8 patients with complete hydatidiform mole (CHM) that evolved into spontaneous remission (SR), 12 patients with CHM that progressed to GTN, and 20 control (C) patients without obstetric complications. Polymorphisms were detected by polymerase chain reaction amplified technique of patients' DNA, and genotype frequencies were compared between the groups. RESULTS: The genotype frequencies of the VEGF 936C/T polymorphism were as follows: SR group, 100% CC genotypeen
dc.description.abstractGTN group, 50.0% CC, 41.7% CT, and 8.3% TTen
dc.description.abstractC group, 30.0% CC, 65.0% CT, and 5.0% TT. Genotype frequencies did not differ significantly between the SR and GTN groups, although a trend was observed (p=0.06). Genotype frequencies did differ significantly between the combined group of all patients with CHM (SR+GTN) and the C group (p=0.03). CONCLUSION: This study did not identify a different VEGF 936C/T genotype profile for patients with CHM who undergo SR versus those who progress to GTN. However, the results do suggest that this polymorphism may affect susceptibility to CHM. Larger groups may improve the results of assessments of the predictive parameters of GTN.en
dc.description.affiliationUniv Fed Sao Paulo, Paulista Med Sch, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Paulista Med Sch, Dept Obstet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq (PIBIC/CNPq - Institutional Programs for Scientific Start-up Grants)
dc.format.extent489-493
dc.identifier.citationJournal Of Reproductive Medicine. St Louis, v. 61, n. 43747, p. 489-493, 2016.
dc.identifier.issn0024-7758
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51091
dc.identifier.wosWOS:000384038100017
dc.language.isoeng
dc.publisherSci Printers & Publ Inc
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectchoriocarcinomaen
dc.subjectgenetic polymorphismen
dc.subjectgestational trophoblastic diseaseen
dc.subjectgestational trophoblastic neoplasiaen
dc.subjecthydatidiform moleen
dc.subjectmolar pregnancyen
dc.subjectpredictorsen
dc.subjectvascular endothelial growth factoren
dc.subjectVEGFen
dc.titleVEGF 936C/T Polymorphism and Gestational Trophoblastic Neoplasiaen
dc.typeinfo:eu-repo/semantics/article
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