Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay

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dc.contributor.authorAntonio, Eliana Maria Restum [UNIFESP]
dc.contributor.authorFontes, Tereza Maria Pereira [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorCarvalho, Adelino Moreira de [UNIFESP]
dc.contributor.authorEspiridião, Silvia [UNIFESP]
dc.contributor.authorNakamura, Mary Uchiyama [UNIFESP]
dc.contributor.authorKulay Júnior, Luiz [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionJose do Rosario Vellano Univ
dc.contributor.institutionABC Med Fdn FUABC
dc.date.accessioned2018-06-15T16:52:39Z
dc.date.available2018-06-15T16:52:39Z
dc.date.issued2012-01-01
dc.description.abstractPurpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.en
dc.description.affiliationUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med FMUSP, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationJose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, Brazil
dc.description.affiliationABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent205-208
dc.identifierhttp://www.irog.net/download/?magazine=21
dc.identifier.citationClinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012.
dc.identifier.issn0390-6663
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43294
dc.identifier.wosWOS:000304899500018
dc.language.isoeng
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRaten
dc.subjectPregnancyen
dc.subjectZidovudineen
dc.subjectStavudineen
dc.subjectAdverse effectsen
dc.titleEffects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essayen
dc.typeinfo:eu-repo/semantics/article
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