Effects of buprenorphine on nociception and spontaneous locomotor activity in horses

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dc.contributor.authorCarregaro, Adriano B.
dc.contributor.authorLuna, Stelio P. L.
dc.contributor.authorMataqueiro, Maria Isabel
dc.contributor.authorQueiroz-Neto, Antonio de
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:58Z
dc.date.available2016-01-24T12:41:58Z
dc.date.issued2007-03-01
dc.description.abstractObjective-To investigate spontaneous locomotor activity (SLA) and antinociceptive effects of buprenorphine in horses.Animals-6 healthy adult horses.Procedures-Horses received each of 3 treatments (10 mL of saline [0.9% NaCl] solution, 5 mu g of buprenorphine/kg, or 10 mu g of buprenorphine/kg). Treatments were administered IV Order of treatments was randomized, and there was a 10-day interval between subsequent treatments. Spontaneous locomotor activity was investigated in a behavioral box by use of infrared photoelectric sensors connected to a computer, which detected movement of each horse. Antinociceptive effect was investigated by hoof-withdrawal reflex latency (HWRL) and skin-twitching reflex latency (STBL) after painful stimulation with a heat lamp.Results-Moderate excitement was observed in all horses from 5 to 10 minutes after the administration of both dosages of buprenorphine. the SLA increased significantly for 6 and 14 hours after IV administration of 5 and 10 mu g of buprenorphine/kg, respectively. Values for HWRL increased significantly only at 30 minutes after injection of 5 mu g of buprenorphine/kg, whereas STRL and HWRL each increased significantly from 1 to 6 hours (except at 2 and 4 hours) and 11 hours, respectively, after injection of 10 mu g of buprenorphine/kg.Conclusions and Clinical Relevance-IV injection of buprenorphine caused a dose-dependent increase in SLA, but only the dose of 10 mu g/kg induced analgesia on the basis of results for the experimental method used.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agrarias & Vet, BR-14884900 Jaboticabal, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent246-250
dc.identifierhttp://dx.doi.org/10.2460/ajvr.68.3.246
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 68, n. 3, p. 246-250, 2007.
dc.identifier.doi10.2460/ajvr.68.3.246
dc.identifier.issn0002-9645
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29586
dc.identifier.wosWOS:000244625700005
dc.language.isoeng
dc.publisherAmer Veterinary Medical Assoc
dc.relation.ispartofAmerican Journal of Veterinary Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleEffects of buprenorphine on nociception and spontaneous locomotor activity in horsesen
dc.typeinfo:eu-repo/semantics/article
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