GABA/benzodiazepine receptors in the ventromedial hypothalamic nucleus regulate both anxiety and panic-related defensive responses in the elevated T-maze

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dc.contributor.authorBueno, Cintia Heloina
dc.contributor.authorZangrossi Junior, Helio
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:49:05Z
dc.date.available2016-01-24T13:49:05Z
dc.date.issued2007-09-14
dc.description.abstractIt has been shown that facilitation of GABA-mediated neurotransmission in the medial nucleus of the amygdala and the dorsal periaqueductal gray (dPAG) inhibits the escape, but not the inhibitory avoidance response generated in the elevated T-maze test of anxiety (ETM). These defensive behaviors have been associated with panic and generalized anxiety, respectively. Previous evidence indicates that the dorsomedial part of the ventromedial hypothalamus (VMHdm), which is interconnected with these two brain areas, is also part of the neurobiological substrate controlling escape behavior. in the present study, we investigated in male Wistar rats whether the intra-VMHdm injection of GABA-modulating drugs differently affect the two defensive tasks measured in the ETNI. the results showed that the microinjection of the benzodiazepine (BZD) receptor agonist midazolam (10, 20 and 40 nmol), the GABA(A) receptor agonist muscimol (2, 4 and 8 nmol) or the GABA(B) receptor agonist baclofen (2, 4 and 8 nmol) impaired inhibitory avoidance and escape performance, an anxiolytic and panicolytic-like effect, respectively. On the other hand, local administration of the BZD inverse agonist FG 7142 (20, 40 and 80 pmol) facilitated both behaviors, suggesting anxiogenic and panicogenic-like effects. These results were not due to motor alterations, since the drugs did not affect exploratory behavior in an open field. the data suggest that GABA(A)/BZD and GABAB receptors within the VMHdm are involved not only in the control of panic-related, but also of anxiety-related behaviors. (c) 2007 Elsevier Inc. All fights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, FFCLRP, Lab Psicofarmacol, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, FMRP, Dept Farmacol, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent134-141
dc.identifierhttps://dx.doi.org/10.1016/j.brainresbull.2007.06.003
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 74, n. 1-3, p. 134-141, 2007.
dc.identifier.doi10.1016/j.brainresbull.2007.06.003
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30041
dc.identifier.wosWOS:000249231300017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectventromedial hypothalamusen
dc.subjectGABAen
dc.subjectElevated T-mazeen
dc.subjectEscapeen
dc.subjectInhibitory avoidanceen
dc.subjectPanicen
dc.subjectGeneralized anxietyen
dc.titleGABA/benzodiazepine receptors in the ventromedial hypothalamic nucleus regulate both anxiety and panic-related defensive responses in the elevated T-mazeen
dc.typeinfo:eu-repo/semantics/article
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