Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval

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dc.citation.issue1
dc.citation.volume130
dc.contributor.authorSoares, Juliana Carlota Kramer [UNIFESP]
dc.contributor.authorPerfetto, Juliano Genaro [UNIFESP]
dc.contributor.authorAntonio, Bruno Brito [UNIFESP]
dc.contributor.authorOliveira, Maria Gabriela Menezes [UNIFESP]
dc.coverageWashington
dc.date.accessioned2020-10-30T18:46:27Z
dc.date.available2020-10-30T18:46:27Z
dc.date.issued2016
dc.description.abstractExtensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, UNIFESP, Rua Botucatu 862,Edificio Ciencias Biomed 1 Andar, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, UNIFESP, Rua Botucatu 862,Edificio Ciencias Biomed 1 Andar, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES)
dc.description.sponsorshipNational Council of Scientific and Technological Development (CNPq)
dc.description.sponsorshipResearch Incentive Fund Association (AFIP)
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.format.extent29-35
dc.identifierhttps://doi.org/10.1037/bne0000113
dc.identifier.citationBehavioral Neuroscience. Washington, v. 130, n. 1, p. 29-35, 2016.
dc.identifier.doi10.1037/bne0000113
dc.identifier.issn0735-7044
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58465
dc.identifier.wosWOS:000370745000004
dc.language.isoeng
dc.publisherAmer Psychological Assoc
dc.relation.ispartofBehavioral Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfear conditioningen
dc.subjectinhibitory avoidanceen
dc.subjectmemory retrievalen
dc.subjectcholinergicen
dc.subjectdicyclomineen
dc.titleEffects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrievalen
dc.typeinfo:eu-repo/semantics/article
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