Early life adversity, genomic plasticity, and psychopathology

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dc.contributor.authorTurecki, Gustavo
dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.contributor.authorJackowski, Andrea [UNIFESP]
dc.contributor.authorKaufman, Joan
dc.contributor.institutionMcGill Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionYale Univ
dc.date.accessioned2018-06-18T10:54:39Z
dc.date.available2018-06-18T10:54:39Z
dc.date.issued2014-11-01
dc.description.abstractChild maltreatment is associated with an increased risk of psychiatric disorders, and a range of health problems later in life. Research suggests that adverse events early in life can lead to changes in gene expression through epigenetic mechanisms that alter stress reactivity, brain function, and behaviour. Although epigenetic changes are often long lasting, they can be reversed with pharmacological and environmental manipulations. The complexity of the epigenome is not fully understood. The aim of this Review is to assess emerging data for the role of epigenetic mechanisms in stress-related psychiatric disorders with a focus on future research. We describe the epigenetic processes, key findings in this specialty, clinical implications of research, and methodological issues. Studies are needed to investigate new epigenetic processes other than methylation and assess the efficacy of interventions to reverse epigenetic processes associated with the effects of early life adversity.en
dc.description.affiliationMcGill Univ, Douglas Mental Hlth Inst, McGill Grp Suicide Studies, Montreal, PQ H4H 1R3, Canada
dc.description.affiliationUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationYale Univ, Sch Med, New Haven, CT USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCanadian Institute of Health Research
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipFonds de Recherche du Quebec-Sante through a Chercheur National salary award
dc.description.sponsorshipFonds de Recherche du Quebec-Sante through the Quebec Network on Suicide, Mood Disorders and Related Disorders
dc.description.sponsorshipIDCanadian Institute of Health Research: MOP93775
dc.description.sponsorshipIDCanadian Institute of Health Research: MOP11260
dc.description.sponsorshipIDCanadian Institute of Health Research: MOP119429
dc.description.sponsorshipIDCanadian Institute of Health Research: MOP119430
dc.description.sponsorshipIDNational Institutes of Health: 1R01DA033684-01
dc.format.extent461-466
dc.identifierhttp://dx.doi.org/10.1016/S2215-0366(14)00022-4
dc.identifier.citationLancet Psychiatry. Oxford: Elsevier Sci Ltd, v. 1, n. 6, p. 461-466, 2014.
dc.identifier.doi10.1016/S2215-0366(14)00022-4
dc.identifier.issn2215-0374
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44818
dc.identifier.wosWOS:000345635400027
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLancet Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.titleEarly life adversity, genomic plasticity, and psychopathologyen
dc.typeinfo:eu-repo/semantics/article
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