The action of CGRP and SP on cultured skin fibroblasts

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dc.contributor.authorHochman, Bernardo [UNIFESP]
dc.contributor.authorTucci-Viegas, Vanina Monique [UNIFESP]
dc.contributor.authorMonteiro, Paola K. P. [UNIFESP]
dc.contributor.authorFranca, Jeronimo Pereira de [UNIFESP]
dc.contributor.authorGaiba, Silvana [UNIFESP]
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Estadual Santa Cruz
dc.date.accessioned2016-01-24T14:37:30Z
dc.date.available2016-01-24T14:37:30Z
dc.date.issued2014-07-01
dc.description.abstractCalcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in the skin, followed by substance P (SP), vasoactive intestinal peptide (VIP), and other neuropeptides in smaller amounts. the proliferative effect of neuropeptides on fibroblasts may affect wound healing and may be associated with hyperproliferative skin and mesenchymal disorders. Understanding the neuropeptidergic action on fibroblasts may provide relevant information to a deeper comprehension of the healing process. This study reviews the action of the main neuropeptides, CGRP and SP, on cultured human skin fibroblasts.A systematic literature search was conducted on Medline and Web of Science databases on December 21, 2013.A total of 74 articles were retrieved using the proposed search strategies and 3 were found in the references section of the selected articles. Thirteen of the retrieved articles studied the action of CGRP and SP on cultured human skin fibroblasts, 12 of which related to SP and 1 related to both CGRP and SP.Only one study was retrieved about the action of both CGRP and SP on cultured human skin fibroblasts. Further studies are necessary to investigate CGRP on skin fibroblasts and its role in the fibroplasia phase of wound healing.en
dc.description.affiliationUniversidade Federal de São Paulo Unifesp, Dept Surg, Plast Surg Div, Postgrad Program Translat Surg, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Estadual Santa Cruz, Dept Agr & Environm Sci, BR-45662900 Ilheus, BA, Brazil
dc.description.affiliationUniv Estadual Santa Cruz, Dept Biol Sci, BR-45662900 Ilheus, BA, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo Unifesp, Dept Surg, Plast Surg Div, Postgrad Program Translat Surg, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent717-726
dc.identifierhttp://dx.doi.org/10.2478/s11535-014-0301-6
dc.identifier.citationCentral European Journal of Biology. Warsaw: de Gruyter Open Ltd, v. 9, n. 7, p. 717-726, 2014.
dc.identifier.doi10.2478/s11535-014-0301-6
dc.identifier.fileWOS000335495900007.pdf
dc.identifier.issn1895-104X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37915
dc.identifier.wosWOS:000335495900007
dc.language.isoeng
dc.publisherDe Gruyter Open Ltd
dc.relation.ispartofCentral European Journal of Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCalcitonin gene-related peptideen
dc.subjectSubstance Pen
dc.subjectFibroblastsen
dc.subjectWound healingen
dc.subjectSkinen
dc.titleThe action of CGRP and SP on cultured skin fibroblastsen
dc.typeinfo:eu-repo/semantics/article
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