The 'brain shadowing sign': a novel marker of fetal craniosynostosis

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dc.contributor.authorHaratz, Karina Krajden [UNIFESP]
dc.contributor.authorLeibovitz, Zvi
dc.contributor.authorSvirsky, Ran
dc.contributor.authorDrummond, Carolina Leite
dc.contributor.authorLev, Dorit
dc.contributor.authorGindes, Liat
dc.contributor.authorLerman-Sagie, Tally
dc.contributor.authorMalinger, Gustavo
dc.date.accessioned2019-01-21T10:29:39Z
dc.date.available2019-01-21T10:29:39Z
dc.date.issued2016
dc.description.abstractIntroduction: The prenatal diagnosis of fetal craniosynostosis is challenging, especially in single-suture cases. When sutures are obliterated, sound waves fail to penetrate the cortical bone, creating an evident acoustic shadow on the underlying brain. The objective of this study was to evaluate the yield of the 'brain shadowing sign' (BSS) as a novel sono-graphic marker for craniosynostosis. Subjects and Methods: Patients with an antenatal diagnosis of fetal craniosynostosis (cases) and healthy controls paired for gestational age were enrolled in this retrospective case-control study. Two-dimensional scans were assessed by three examiners for the presence of the BSS and additional fetal findings. Results: The BSS was clearly depicted in all 24 cases on the first anal- ysis and in 22 cases on the second analysis. No fetus from the control group (n = 48) presented the BSS in any of the analyses. Fifteen cases had isolated craniosynostosis and 9 were syndromic (Apert, Saethre-Chotzen and craniofrontonasal syndromes), which were diagnosed significantly earlier due to additional malformations. Discussion: The BSS is a novel sonographic marker of craniosynostosis which can be used to increase the diagnostic rate of this rare condition and does not require the use of high-definition three-dimensional transducers to be depicted. (C) 2016 S. Karger AG, Baselen
dc.description.affiliationDivision of Prenatal Diagnosis, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon
dc.description.affiliationGenetics Institute, Wolfson Medical Center, Holon
dc.description.affiliationPediatric Neurology Unit, Wolfson Medical Center, Holon
dc.description.affiliationDepartment of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa
dc.description.affiliationObstetric-Gynecologic Ultrasound Unit, Department of Obstetrics and Gynecology, Asa
dc.description.affiliationHarofeh Medical Center, Beer Yaakov
dc.description.affiliationGenetics Institute, Tel Aviv Sourasky Medical Center
dc.description.affiliationObstetric-Gynecologic Ultrasound Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
dc.description.affiliationDepartment of Gynecology and Obstetrics, Fetal Medicine Unit, Hospital Israelita Albert Einstein
dc.description.affiliationDepartment of Obstetrics, Fetal Medicine Division, Federal University of São Paulo
dc.description.affiliationCentro Paulista de Medicina Fetal, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Obstetrics, Fetal Medicine Division, Federal University of São Paulo, and jCentro Paulista de Medicina Fetal, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent277-284
dc.identifierhttps://doi.org/10.1159/000444298
dc.identifier.citationFetal Diagnosis And Therapy. Basel, v. 40, n. 4, p. 277-284, 2016.
dc.identifier.doi10.1159/000444298
dc.identifier.issn1015-3837
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49308
dc.identifier.wosWOS:000390550600005
dc.language.isoeng
dc.publisherBmj Publishing Group
dc.relation.ispartofFetal Diagnosis And Therapy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCraniosynostosisen
dc.subjectPrenatal Diagnosisen
dc.subjectFetal Neurosonographyen
dc.subjectSagittal Synostosisen
dc.subjectFetal Anomaliesen
dc.subjectFetal BrainUltrasound Diagnosisen
dc.subjectApert-Syndromeen
dc.titleThe 'brain shadowing sign': a novel marker of fetal craniosynostosisen
dc.typeinfo:eu-repo/semantics/article
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