The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovarieetomized mice

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dc.contributor.authorDe Oliveira, Flavia [UNIFESP]
dc.contributor.authorMaifrino, Laura Beatriz Mesiano [UNIFESP]
dc.contributor.authorJesus, Gustavo Protasio Pacheco de [UNIFESP]
dc.contributor.authorCarvalho, Juliana Goncalves [UNIFESP]
dc.contributor.authorMarchon, Claudia
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Sao Judas Tadeu
dc.contributor.institutionInst Dante Pazzanese Cardiol
dc.date.accessioned2018-06-15T13:50:09Z
dc.date.available2018-06-15T13:50:09Z
dc.date.issued2013-09-01
dc.description.abstractEstrogen deprivation in postmenopausal women increases cardiovascular risk. Cardiovascular risk as a result of atherosclerosis is able to induce an inflammatory disease as far as cyclooxygenase-2 (COX-2) expression. The purpose of the study was to investigate the role of COX-2 on exercise training in female mice low-density lipoprotein receptor knockout (LDL-KO) with or without ovariectomy. A total of 15 female C57BL/6 mice and 15 female LDE-KO mice were distributed into 6 groups: sedentary control, sedentary control ovariectomized, trained control ovariectomized, LDL-KO sedentary, LDL-KO sedentary ovariectomized and LDL-KO trained ovariectomized. The ascending part of the aorta was stained with H&E and COX-2 expression was assessed by immunohistochemistry. Results revealed that ovariectomy as well as exercise training were not able to induce histopathological changes in mouse aorta for all groups investigated. LDL-KO mice demonstrated plaque containing cholesterol clefts, foamy histiocytes and mild inflammatory process for all groups indistinctly. Ovariectomy induced a strong immunoexpression in atherosclerosis lesion of EDE-KO mice. Nevertheless, a down-regulation of COX-2 expression was detected in LDL-KO trained ovariectomized when compared to LDE-KO sedentary. Our results are consistent with the notion that exercise training is able to modulate COX-2 expression in LDL-KO mice as a result of COX-2 down-regulation.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Lab Anal Morfoquantitat & Imunohistoquim, BR-03166000 Sao Paulo, Brazil
dc.description.affiliationInst Dante Pazzanese Cardiol, BR-04012180 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1157-1164
dc.identifierhttps://dx.doi.org/10.1590/S0001-37652013005000046
dc.identifier.citationAnais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 85, n. 3, p. 1157-1164, 2013.
dc.identifier.doi10.1590/S0001-37652013005000046
dc.identifier.fileS0001-37652013005000046.pdf
dc.identifier.issn0001-3765
dc.identifier.scieloS0001-37652013005000046
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/42529
dc.identifier.wosWOS:000324948400031
dc.language.isoeng
dc.publisherAcad Brasileira De Ciencias
dc.relation.ispartofAnais Da Academia Brasileira De Ciencias
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtherosclerosisen
dc.subjectCiclooxygenase-2en
dc.subjectExerciseen
dc.subjectMenopauseen
dc.titleThe role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovarieetomized miceen
dc.typeinfo:eu-repo/semantics/article
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