Chagas' disease: an update on immune mechanisms and therapeutic strategies

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dc.contributor.authorBoscardin, Silvia Beatriz
dc.contributor.authorTroccoli Torrecilhas, Ana Claudia
dc.contributor.authorManarin, Romina
dc.contributor.authorRevelli, Silvia
dc.contributor.authorGonzalez Rey, Elena
dc.contributor.authorTonelli, Renata Rosito [UNIFESP]
dc.contributor.authorSilber, Ariel Mariano
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionMackenzie Presbeterian Univ
dc.contributor.institutionNatl Univ Rosario
dc.contributor.institutionCSIC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:43Z
dc.date.available2016-01-24T13:59:43Z
dc.date.issued2010-06-01
dc.description.abstractThe final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Parasitol, São Paulo, Brazil
dc.description.affiliationMackenzie Presbeterian Univ, Ctr Biomol Sci & Hlth, São Paulo, Brazil
dc.description.affiliationNatl Univ Rosario, Sch Med Sci, Inst Immunol, Rosario, Santa Fe, Argentina
dc.description.affiliationCSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto Nacional de Biologia Estrutural e QuImica Medicinal em Doencas Infecciosas (INBEQMeDI)
dc.description.sponsorshipIDFAPESP: 08/57596-4
dc.description.sponsorshipIDFAPESP: 07/08648-9
dc.description.sponsorshipIDCNPq: 473906/2008-2
dc.format.extent1373-1384
dc.identifierhttp://dx.doi.org/10.1111/j.1582-4934.2010.01007.x
dc.identifier.citationJournal of Cellular and Molecular Medicine. Malden: Wiley-Blackwell, v. 14, n. 6B, p. 1373-1384, 2010.
dc.identifier.doi10.1111/j.1582-4934.2010.01007.x
dc.identifier.fileWOS000292023100001.pdf
dc.identifier.issn1582-1838
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32564
dc.identifier.wosWOS:000292023100001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectChagas' diseaseen
dc.subjectTrypanosoma cruzien
dc.subjectimmunityen
dc.subjectchemotherapyen
dc.subjectimmunoparasitologyen
dc.titleChagas' disease: an update on immune mechanisms and therapeutic strategiesen
dc.typeinfo:eu-repo/semantics/article
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