Efficacy of the FEV1/FEV6 ratio compared to the FEV1/FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over

Página do item simplificado
dc.contributor.authorRosa, Fernanda Warken [UNIFESP]
dc.contributor.authorPérez-Padilla, Rogelio
dc.contributor.authorCamelier, Aquiles Assunção [UNIFESP]
dc.contributor.authorNascimento, Oliver Augusto [UNIFESP]
dc.contributor.authorMenezes, Ana Maria Baptista
dc.contributor.authorJardim, José Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Católica do Salvador
dc.contributor.institutionFaculdade de Tecnologia e Ciências
dc.contributor.institutionNational Institute of Respiratory Diseases
dc.contributor.institutionUniversidade Federal da Bahia Disciplina de Pneumologia
dc.contributor.institutionUniversidade Federal de Pelotas Programa de Pós-graduação em Epidemiologia
dc.contributor.institutionPLATINO Group
dc.date.accessioned2015-06-14T13:37:16Z
dc.date.available2015-06-14T13:37:16Z
dc.date.issued2007-12-01
dc.description.abstractThe present cross-sectional, population-based study was designed to evaluate the performance of the FEV1/FEV6 ratio for the detection of airway-obstructed subjects compared to the FEV1/FVC <0.70 fixed ratio test, as well as the lower limit of normality (LLN) for 1000 subjects ³40 years of age in the metropolitan area of São Paulo, SP, Brazil. After the exclusion of 37 (3.7%) spirometries, a total of 963 pre-bronchodilator (BD) and 918 post-BD curves were constructed. The majority of the post-BD curves (93.1%) were of very good quality and achieved grade A (762 curves) or B (93 curves). The FEV1/FEV6 and FEV1/FVC ratios were highly correlated (r² = 0.92, P < 0.000). Two receiver operator characteristic curves were constructed in order to express the imbalance between the sensitivity and specificity of the FEV1/FEV6 ratio compared to two FEV1/FVC cut-off points for airway obstruction: equal to 70 (area under the curve = 0.98, P < 0.0001) and the LLN (area under the curve = 0.97, P < 0.0001), in the post-BD curves. According to an FEV1/FVC <0.70, the cut-off point for the FEV1/FEV6 ratio with the highest sum for sensitivity and specificity was 0.75. The FEV1/FEV6 ratio can be considered to be a good alternative to the FEV1/FVC ratio for the diagnosis of airway obstruction, both using a fixed cut-off point or below the LLN as reference. The FEV1/FEV6 ratio has the additional advantage of being an easier maneuver for the subjects and for the lung function technicians, providing a higher reproducibility than traditional spirometry maneuvers.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Pneumologia e Centro de Reabilitação Pulmonar
dc.description.affiliationUniversidade Católica do Salvador
dc.description.affiliationFaculdade de Tecnologia e Ciências
dc.description.affiliationNational Institute of Respiratory Diseases
dc.description.affiliationUniversidade Federal da Bahia Disciplina de Pneumologia
dc.description.affiliationUniversidade Federal de Pelotas Programa de Pós-graduação em Epidemiologia
dc.description.affiliationPLATINO Group
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Pneumologia e Centro de Reabilitação Pulmonar
dc.description.sourceSciELO
dc.format.extent1615-1621
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2006005000182
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 12, p. 1615-1621, 2007.
dc.identifier.doi10.1590/S0100-879X2006005000182
dc.identifier.fileS0100-879X2007001200004.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2007001200004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4072
dc.identifier.wosWOS:000252843900004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectForced expiratory volume in six secondsen
dc.subjectAirway obstructionen
dc.subjectDiagnosisen
dc.subjectForced vital capacityen
dc.subjectPulmonary function testsen
dc.subjectSpirometryen
dc.titleEfficacy of the FEV1/FEV6 ratio compared to the FEV1/FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or overen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0100-879X2007001200004.pdf
Tamanho:
487.94 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos