Avaliação da síntese intratecal de imunoglobulinas no transplante de medula óssea

Página do item simplificado
dc.contributor.authorAlmeida, Sergio Monteiro de [UNIFESP]
dc.contributor.authorLivramento, Jose Antonio
dc.contributor.authorPasquini, Ricardo
dc.contributor.authorPalou, Viviana Boccardi
dc.contributor.authorOliveira, Aparecido Mendes de
dc.contributor.authorDoi, Elvira Missako
dc.contributor.authorOno, Margaret
dc.contributor.authorAso, Mirna Cigemi
dc.contributor.authorFerreira, Euripedes [UNIFESP]
dc.contributor.institutionUNIV FED PARANA
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T14:00:13Z
dc.date.available2018-06-15T14:00:13Z
dc.date.issued1997-12-01
dc.description.abstractThe central nervous system involvement in chronic graft versus host disease (GVHD) has been suggested. Chronic GVHD resembles auto immune connective tissue disorders. In order to investigate the immunoglobulin intra blood brain barrier (BBB) synthesis during chronic GVHD, and contribute to understanding the pathophysiology of the disease, we studied 33 patients who underwent allogeneic bone marrow transplants (BMT) from HLA identical related donors. Immunoglobulin intra BBB synthesis was investigated quantitative and qualitatively. The samples were collected pre BMT, pos BMT and during chronic GVHD. There were no evidence of immunoglobulin intra BBB synthesis, and no oligoclonal bands were found. Only isolated cases suggested IgG and IgA intra BBB synthesis, and in one case IgM during GVHD.en
dc.description.affiliationUNIV FED PARANA,HOSP CLIN,SERV TMO,BR-80060900 CURITIBA,PARANA,BRAZIL
dc.description.affiliationUNIV FED PARANA,HOSP CLIN,DISCIPLINA NEUROL,BR-80060900 CURITIBA,PARANA,BRAZIL
dc.description.affiliationUNIFESP,ESCOLA PAULISTA MED,DISCIPLINA IMUNOL,SAO PAULO,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC MED,CTR INVEST NEUROL,BR-05508 SAO PAULO,BRAZIL
dc.description.affiliationUnifespUNIFESP,ESCOLA PAULISTA MED,DISCIPLINA IMUNOL,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent801-811
dc.identifierhttp://dx.doi.org/10.1590/S0004-282X1997000500018
dc.identifier.citationArquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos De Neuro- Psiquiatria, v. 55, n. 4, p. 801-811, 1997.
dc.identifier.doi10.1590/S0004-282X1997000500018
dc.identifier.fileS0004-282X1997000500018.pdf
dc.identifier.issn0004-282X
dc.identifier.scieloS0004-282X1997000500018
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42729
dc.identifier.wosWOS:A1997YJ09100018
dc.language.isopor
dc.publisherAssoc Arquivos De Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgraft-versus-host diseaseen
dc.subjectblood-brain barrieren
dc.subjectauto immunityen
dc.subjectimmunoglobulinsen
dc.subjectcerebrospinal fluiden
dc.subjectbone marrow transplantationen
dc.titleAvaliação da síntese intratecal de imunoglobulinas no transplante de medula ósseapt
dc.title.alternativeImmunoglobulins intrathecal synthesis evaluation in bone marrow transplantationen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos