Evaluation of in vitro and in vivo safety of the by-product of Agave sisalana as a new cosmetic raw material: Development and clinical evaluation of a nanoemulsion to improve skin moisturizing

Página do item simplificado
dc.citation.volume108
dc.contributor.authorAndrade Gomes Barreto, Stella Maria
dc.contributor.authorMaia, Mayara Saatman
dc.contributor.authorBenica, Alvaro Moreira
dc.contributor.authorBezerra Silva de Assis, Hugo Raphael
dc.contributor.authorLeite-Silva, Vania Rodrigues [UNIFESP]
dc.contributor.authorda Rocha-Filho, Pedro Alves
dc.contributor.authorFernandes de Negreiros, Marilia Medeiros
dc.contributor.authorde Oliveira Rocha, Hugo Alexandre
dc.contributor.authorOstrosky, Elissa Arantes
dc.contributor.authorLopes, Patricia Santos [UNIFESP]
dc.contributor.authorde Farias Sales, Valeria Soraya
dc.contributor.authorGiordani, Raquel Brandt
dc.contributor.authorFerrari, Marcio
dc.coverageAmsterdam
dc.date.accessioned2020-09-01T13:21:14Z
dc.date.available2020-09-01T13:21:14Z
dc.date.issued2017
dc.description.abstractAgave sisalana (sisal) is the important global source of hard fiber, which is widely used in the production of wires, ropes, and handicrafts. The decortication process of the A. sisalana leaf produces large amounts of by-product that is discarded and can cause environmental damage. Studies have shown the potential of the by-product of A. sisalana in different applications. The aim of this study was to obtain a polysaccharide-enriched fraction (EF) from the by-product of A. sisalana, assess its safety in vitro and in vivo, to develop a cosmetic nanoemulsion and to evaluate its moisturizing clinical efficacy. EF was obtained and total sugar, total phenolic, and protein content were quantified. The safety of EF was determined using in vitro and in vivo assays. Nanoemulsions were developed and their stability evaluated for 90 days at different temperature conditions. The clinical moisturizing efficacy was evaluated by biophysical techniques using capacitance measurement and transepidermal Water loss. The fraction exhibited high concentrations of sugar (65.49 +/- 0.51%) and the presence of phenolic compounds (2.53 +/- 0.04%) as well as protein (0.04 +/- 0.01%). The EF did not exhibit potential cytotoxic or phototoxic effects and did not present the potential to induce skin irritant reaction in clinical tests. Nanoemulsion containing 40% oil phase, 50% aqueous phase and 10% surfactants, added fraction or not (vehicle), was stable for 90 days. The nanoemulsion containing 0.5% of the fraction increased the water content of stratum cornetun by 10.13% vs. vehicle and by 19.28% vs. baseline values and maintained skin barrier function after 5 h of a single application. The EF obtained from the industrial by-product of A. sisalana demonstrated a promising profile as a moisturizing cosmetic raw material. This is important because it shows the possibility to increase the commercial value to the industrial by-product of sisal, and thus reduce the environmental impact caused by the disposal of this material.en
dc.description.affiliationFed Univ Rio Grande do Norte UFRN, Coll Pharm, Rua Gustavo Cordeiro de Farias S-N, BR-59012570 Natal, RN, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Ciencias Exatas & Terra, Rua Sao Nicolau 210, BR-09913030 Diadema, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Ave Cafe S-N, BR-19040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationFed Univ Rio Grande do Norte UFRN, Dept Biochem, Ave Salgado Filho S-N, BR-59078970 Natal, RN, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Ciencias Exatas & Terra, Rua Sao Nicolau 210, BR-09913030 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFederal University of Rio Grande do Norte (UFRN)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipComissão de Aperfeicoamento de Pessoal do Nivel Superior (CAPES)
dc.format.extent470-479
dc.identifierhttp://dx.doi.org/10.1016/j.indcrop.2017.06.064
dc.identifier.citationIndustrial Crops And Products. Amsterdam, v. 108, p. 470-479, 2017.
dc.identifier.doi10.1016/j.indcrop.2017.06.064
dc.identifier.issn0926-6690
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58150
dc.identifier.wosWOS:000412959800054
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofIndustrial Crops And Products
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAgave sisalana by-producten
dc.subjectCosmeticen
dc.subjectSafetyen
dc.subjectNanoemulsionen
dc.subjectMoisturizingen
dc.titleEvaluation of in vitro and in vivo safety of the by-product of Agave sisalana as a new cosmetic raw material: Development and clinical evaluation of a nanoemulsion to improve skin moisturizingen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
ICAQF - Artigos