Serum homocysteine and cysteine levels and associated factors in children and adolescents

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dc.citation.issue1
dc.citation.volume37
dc.contributor.authorCosta, Priscila Ribas de Farias
dc.contributor.authorKinra, Sanjay
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.authorAssis, Ana Marlucia Oliveira
dc.coverageMadrid
dc.date.accessioned2020-07-31T12:46:41Z
dc.date.available2020-07-31T12:46:41Z
dc.date.issued2017
dc.description.abstractIntroduction: Studies have identified high serum homocysteine ( Hcy) and cysteine ( Cys) levels as risk factor for cardiovascular diseases, important cause of death in all world. The factors associated with high levels of these biochemistry markers in adults are well knownen
dc.description.abstracthowever, data are sparse on these associations in the pediatric age group. Objective: the objective was to identify factors associated with different concentrations of serum Hcy and Cys in children and adolescents. Methods: a cross-sectional study with 483 individuals of 715 years of age of both sexes, from a municipality of Bahia. Serum Hcy and Cys levels were considered outcome variables, with exposure being evaluated according to sociodemographic, clinical, biochemical and lifestyle variables. Polytomous logistic regression was used to evaluate the association between exposure and outcome. Results: high serum Hcy levels were associated with being male (PR=3.74en
dc.description.abstractp<0.01), age =12 years (PR=2.56en
dc.description.abstractp<0.01), being overweight (PR=2.32en
dc.description.abstractp=0.02), high blood pressure (PR=1.97en
dc.description.abstractp<0.01), low HDL-c levels (PR=1.21en
dc.description.abstractp=0.03), high triglyceride levels (PR=1.62en
dc.description.abstractp=0.03) and poor intake of foods that protect against hyperhomocysteinemia (PR=1.46en
dc.description.abstractp=0.02). High serum Cys levels were associated with age =12 years (PR=2.1en
dc.description.abstractp=0.03), being overweight (PR=2.52en
dc.description.abstractp=0.03)en
dc.description.abstracthigh blood pressure (PR=1.28en
dc.description.abstractp=0.03), low HDL-c levels (PR=1.15en
dc.description.abstractp=0.01), high triglyceride levels (PR=1.41en
dc.description.abstractp=0.02) and poor intake of foods that protect against hyper-cysteinemia (PR=1.46en
dc.description.abstractp=0.01). Conclusions: age > 12 years, being overweight, high blood pressure, low HDL-c levels, high triglyceride levels and poor intake of protective foods are common factors found in individuals with increased serum Hcy and Cys levels. Being male was associated with high serum Hcy levels alone. Considering that these factors are already present early in life, measures should be adopted to prevent and control high Hcy and Cys levels, promoting health and preventing chronic non-communicable diseases at this stage of life.en
dc.description.affiliationUniv Fed Bahia, Publ Hlth Inst ISC, Salvador, BA, Brazil
dc.description.affiliationUniv Fed Bahia, Dept Nutr Sci, Salvador, BA, Brazil
dc.description.affiliationLondon Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Vila Clementino, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Vila Clementino, São Paulo-SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent106-116
dc.identifierhttp://dx.doi.org/10.12873/371ribasdefarias
dc.identifier.citationNutricion Clinica Y Dietetica Hospitalaria. Madrid, v. 37, n. 1, p. 106-116, 2017.
dc.identifier.doi10.12873/371ribasdefarias
dc.identifier.issn0211-6057
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56312
dc.identifier.wosWOS:000400444300013
dc.language.isoeng
dc.publisherSoc Espanola Dietetica & Ciencias Alimentacion-Sedca
dc.relation.ispartofNutricion Clinica Y Dietetica Hospitalaria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHomocysteineen
dc.subjectcysteineen
dc.subjectassociated factorsen
dc.subjectChildrenen
dc.subjectadolescentsen
dc.titleSerum homocysteine and cysteine levels and associated factors in children and adolescentsen
dc.typeinfo:eu-repo/semantics/article
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