Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease

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dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorPrado, Wagner Luiz do [UNIFESP]
dc.contributor.authorCaranti, Danielle Arisa [UNIFESP]
dc.contributor.authorSiqueira, Kãli de Oliveira [UNIFESP]
dc.contributor.authorStella, Sérgio Garcia [UNIFESP]
dc.contributor.authorLofrano-Prado, Mara Cristina [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorCristofalo, Dejaldo J. M. [UNIFESP]
dc.contributor.authorLederman, Henrique Manoel [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:59Z
dc.date.available2016-01-24T12:41:59Z
dc.date.issued2007-04-01
dc.description.abstractBackground: the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing due to its prevalence in obesity, diabetes, and insulin-resistance syndrome. the best treatment protocol for NAFLD has not been determined. However, there is evidence that exercise and nutritional intervention can improve and prevent it. the aim of the present study was to evaluate the dietary and metabolic profiles of obese adolescents with NAFLD who participated in a multidisciplinary program.Patients and Methods: We studied 43 adolescents ages 15 to 19 years (17.18 +/- 1.66 years) with a body mass index (BMI) >= 30, consisting of 30 patients without NAFLD (BMI = 35.80 +/- 3.44 kg/m(2)) and 13 with NAFLD (BMI=33.4 +/- 2.34kg/m(2)). the NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic aminotransferase levels, and lipid profiles. Insulin resistance was measured by homeostasis model assessment insulin-resistance index (HOMA-IR). the analyses of baseline and postintervention food intake were made by a 3-day inquiry.Results: At baseline conditions, the patients with NAFLD showed significant differences in body mass, BMI, and visceral and subcutaneous fat. Glucose and visceral and subcutaneous fat presented a significant reduction after treatment in patients with NAFLD. Analyzing the food intake, at baseline we observed a positive correlation between the visceral obesity and lipid consumption only in patients with NAFLD. We also observed significant decrease in energy and cholesterol consumption in patients with NAFLD after the multidisciplinary therapy.Conclusions: the intervention promoted a decrease in the prevalence of NAFLD, a significant decrease in visceral obesity, and improved HOMA-IR, glycemia, and serum lipid levels that are risk factors for NAFLD. in summary, the multidisciplinary program is essential in the treatment and prevention of NAFLD.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent446-452
dc.identifierhttps://dx.doi.org/10.1097/MPG.0b013e31803815d9
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 44, n. 4, p. 446-452, 2007.
dc.identifier.doi10.1097/MPG.0b013e31803815d9
dc.identifier.issn0277-2116
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29601
dc.identifier.wosWOS:000245260400009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFood intakeen
dc.subjectNutritionen
dc.subjectVisceral adipose tissueen
dc.titleMetabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver diseaseen
dc.typeinfo:eu-repo/semantics/article
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