IMMUNOHISTOCHEMICAL EVALUATION of UVEAL MELANOCYTIC TUMORS - EXPRESSION of HMB-45, S-100 PROTEIN, and NEURON-SPECIFIC ENOLASE
| dc.contributor.advisor | ||
| dc.contributor.author | Burnier Junior, Miguel Noel [UNIFESP] | |
| dc.contributor.author | Mclean, I. W. | |
| dc.contributor.author | Gamel, J. W. | |
| dc.contributor.institution | ARMED FORCES INST PATHOL | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.contributor.institution | UNIV LOUISVILLE | |
| dc.date.accessioned | 2016-01-24T11:40:03Z | |
| dc.date.available | 2016-01-24T11:40:03Z | |
| dc.date.issued | 1991-08-15 | |
| dc.description.abstract | The authors compared the immunohistochemical reactivity of 13 uveal nevi and 20 uveal melanomas for HMB-45, S-100 protein, and neuron-specific enolase (NSE) in formalin-fixed, paraffin-embedded sections. All 33 of the lesions were positive for HMB-45. the false-negative rates for S-100 protein and NSE were 21% and 18%, respectively. If only strongly positive reactions were considered, more than 50% of the tumors would be interpreted as negative for S-100 protein and NSE. Nevi stained with less intensity than melanomas using all three antibodies. the expression of HMB-45 appeared to be greater in active nevi than in inactive nevi. There was a weak association between S-100 protein reactivity and the ability of the uveal melanomas to metastasize (P = 0.1); however, the standard deviation of nucleolar area was a much better predictor (P = 0.02). These results indicate that pathologists will find HMB-45 to be a useful tool in differentiating uveal melanoma from nonmelanocytic tumors. | en |
| dc.description.affiliation | ARMED FORCES INST PATHOL,DEPT OPHTHALM,WASHINGTON,DC 20306 | |
| dc.description.affiliation | ESCOLA PAULISTA MED SCH,BRAZILIAN REGISTRY OPHTHALM PATHOL,BR-04023 São Paulo,BRAZIL | |
| dc.description.affiliation | UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT OPHTHALMOL,LOUISVILLE,KY 40202 | |
| dc.description.affiliationUnifesp | ESCOLA PAULISTA MED SCH,BRAZILIAN REGISTRY OPHTHALM PATHOL,BR-04023 São Paulo,BRAZIL | |
| dc.description.source | Web of Science | |
| dc.format.extent | 809-814 | |
| dc.identifier | http://dx.doi.org/10.1002/1097-0142(19910815)68:4<809 | |
| dc.identifier.citation | Cancer. New York: Wiley-liss, v. 68, n. 4, p. 809-814, 1991. | |
| dc.identifier.doi | 10.1002/1097-0142(19910815)68:4<809 | |
| dc.identifier.issn | 0008-543X | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/25214 | |
| dc.identifier.wos | WOS:A1991FY94700023 | |
| dc.language.iso | eng | |
| dc.publisher | Wiley-Blackwell | |
| dc.relation.ispartof | Cancer | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
| dc.title | IMMUNOHISTOCHEMICAL EVALUATION of UVEAL MELANOCYTIC TUMORS - EXPRESSION of HMB-45, S-100 PROTEIN, and NEURON-SPECIFIC ENOLASE | en |
| dc.type | info:eu-repo/semantics/article |