Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium

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dc.contributor.authorPrior, Pedro Luis [UNIFESP]
dc.contributor.authorGalduróz, José Carlos Fernandes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:07Z
dc.date.available2016-01-24T14:17:07Z
dc.date.issued2011-09-01
dc.description.abstractIt is known that the glutamatergic pathways are hyperfunctioning during alcohol withdrawal syndrome. It has been demonstrated that hyperfunctioning of this system causes a great damage to the superior cortical activity, the ability to concentrate and the control of impulses. Recent studies show that the cations zinc and magnesium modulate the glutamatergic function, reducing it to non-toxic levels, yet not reducing it to the point of depriving this neurotransmitter of its normal activity. New perspectives of treatment focus on the modulation of this system, having, as a result, reestablishment of impulse control abilities, damage prevention to the hippocampus and the amygdala and prevention of future relapses. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent368-370
dc.identifierhttp://dx.doi.org/10.1016/j.mehy.2011.05.017
dc.identifier.citationMedical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 3, p. 368-370, 2011.
dc.identifier.doi10.1016/j.mehy.2011.05.017
dc.identifier.fileWOS000295183500014.pdf
dc.identifier.issn0306-9877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33973
dc.identifier.wosWOS:000295183500014
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGlutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesiumen
dc.typeinfo:eu-repo/semantics/article
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