Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases

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dc.contributor.authorDellavance, A.
dc.contributor.authorAlvarenga, R. R. [UNIFESP]
dc.contributor.authorRodrigues, S. H. [UNIFESP]
dc.contributor.authorKok, F.
dc.contributor.authorSouza, A. W. S. de [UNIFESP]
dc.contributor.authorAndrade, L. E. C. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFleury Grp
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:17:53Z
dc.date.available2016-01-24T14:17:53Z
dc.date.issued2012-02-01
dc.description.abstractBackground and purposes: Anti-aquaporin 4 antibodies are specific markers for Devics disease. This study aimed to test if this high specificity holds in the context of a large spectrum of systemic autoimmune and non-autoimmune diseases.Methods: Anti-aquaporin-4 antibodies (NMO-IgG) were determined by indirect immunofluorescence (IIF) on mouse cerebellum in 673 samples, as follows: group I (clinically defined Devic's disease, n = 47); group II [ inflammatory/demyelinating central nervous system (CNS) diseases, n = 41]; group III (systemic and organ-specific autoimmune diseases, n = 250); group IV (chronic or acute viral diseases, n = 35); and group V (randomly selected samples from a general clinical laboratory, n = 300).Results: MNO-IgG was present in 40/47 patients with classic Devic's disease (85.1% sensitivity) and in 13/22 (59.1%) patients with disorders related to Devic's disease. the latter 13 positive samples had diagnosis of longitudinally extensive transverse myelitis (n = 10) and isolated idiopathic optic neuritis (n = 3). One patient with multiple sclerosis and none of the remaining 602 samples with autoimmune and miscellaneous diseases presented NMO-IgG (99.8% specificity). the autoimmune disease subset included five systemic lupus erythematosus individuals with isolated or combined optic neuritis and myelitis and four primary Sjogren's syndrome (SS) patients with cranial/peripheral neuropathy.Conclusions: the available data clearly point to the high specificity of anti-aquaporin-4 antibodies for Devic's disease and related syndromes also in the context of miscellaneous non-neurologic autoimmune and non-autoimmune disorders.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Rheumatol, UNIFESP, BR-04023062 São Paulo, Brazil
dc.description.affiliationFleury Grp, Div Res & Dev, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Rheumatol, UNIFESP, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipResearch and Development Division, Fleury Group
dc.format.extent248-252
dc.identifierhttp://dx.doi.org/10.1111/j.1468-1331.2011.03479.x
dc.identifier.citationEuropean Journal of Neurology. Malden: Wiley-Blackwell, v. 19, n. 2, p. 248-252, 2012.
dc.identifier.doi10.1111/j.1468-1331.2011.03479.x
dc.identifier.issn1351-5101
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34608
dc.identifier.wosWOS:000299255300014
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofEuropean Journal of Neurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectAQP4 antibodyen
dc.subjectaquaporin-4en
dc.subjectmyasthenia gravisen
dc.subjectneuromyelitis Opticaen
dc.subjectNMO-IgGen
dc.subjectSjogren's syndromeen
dc.subjectsystemic lupus erythematosusen
dc.titleAnti-aquaporin-4 antibodies in the context of assorted immune-mediated diseasesen
dc.typeinfo:eu-repo/semantics/article
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