The Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Disease

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dc.citation.issue2
dc.citation.volumev. 40
dc.contributor.authorAdegoke, Samuel Ademola [UNIFESP]
dc.contributor.authorBraga, Josefina Aparecida Pellegrini [UNIFESP]
dc.contributor.authorAdekile, Adekunle D.
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-20T16:31:21Z
dc.date.available2020-07-20T16:31:21Z
dc.date.issued2018
dc.description.abstractAlthough vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017en
dc.description.abstractr=0.45, P=0.006, respectively)en
dc.description.abstractinverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0.44, P=0.008en
dc.description.abstractr=-0.47, P=0.007en
dc.description.abstractr=-0.45, P=0.007, respectively). In VDD groups, Hb was lower (P=0.014), reticulocyte counts and LDH were higher (P=0.047 and 0.003, respectively). Serum 25-hydroxyvitamin D correlated with biomarkers of hemolysis in SCD and VDD may play a role in SCD pathogenesis.en
dc.description.affiliationEscola Paulista Med, Haematol & Blood Transfus Div, Sao Paulo, SP, Brazil
dc.description.affiliationObafemi Awolowo Univ, Dept Pediat & Child Hlth, PMB 013, Ife, Nigeria
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationKuwait Univ, Dept Paediat, Fac Med, Kuwait, Kuwait
dc.description.affiliationUnifespEscola Paulista Med, Haematol & Blood Transfus Div, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES/SUS (Coordination of Improvement of Higher Level Personnel)
dc.description.sponsorshipBrazil National Council for Research (CNPq)
dc.format.extent159-162
dc.identifierhttp://dx.doi.org/10.1097/MPH.0000000000000783
dc.identifier.citationJournal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 2, p. 159-162, 2018.
dc.identifier.doi10.1097/MPH.0000000000000783
dc.identifier.issn1077-4114
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55892
dc.identifier.wosWOS:000428181500033
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Pediatric Hematology Oncology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbiomarkersen
dc.subjecthemolysisen
dc.subjectpediatric sickle cell diseaseen
dc.subject25-hydroxyvitamin Den
dc.titleThe Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Diseaseen
dc.typeinfo:eu-repo/semantics/article
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