Schistosonia mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration

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dc.contributor.authorBahia, Diana
dc.contributor.authorMortara, Renato A.
dc.contributor.authorKusel, John R.
dc.contributor.authorAndrade, Luiza F.
dc.contributor.authorLudolf, Fernanda
dc.contributor.authorKuser, Paula R.
dc.contributor.authorAvelar, Livia
dc.contributor.authorTrolet, Jacques
dc.contributor.authorDissous, Colette
dc.contributor.authorPierce, Raymond J.
dc.contributor.authorOliveira, Guilherme
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniv Glasgow
dc.contributor.institutionPrograma Pos Grad & Pequisa
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionINSERM
dc.contributor.institutionUniv Lille 2
dc.contributor.institutionInst Pasteur
dc.date.accessioned2016-01-24T13:48:51Z
dc.date.available2016-01-24T13:48:51Z
dc.date.issued2007-07-01
dc.description.abstractProtein Tyrosine Kinases (PTKs) are important molecules in intra- and inter-cellular communication, playing a major role in signal transduction processes. We have previously identified and characterized the molecular structure of a new PTK in Schistosoma mansoni, SmFes. SmFes exhibits the characteristic features of Fes/Fps protein tyrosine kinase subfamily of which it is the first member described in helminths. Herein, we show that genes orthologous to SmFes are also present in other Schistosoma species and the transcript is detected in Schistosoma japonicum. the SmFes protein was detected at all the main life-cycle stages and was most abundant in cercariae and newly-transformed schistosomula. However, no protein was detected in schistosomula maintained in vitro for 7 days. By immunolocalization assays we showed that SmFes is particularly concentrated at the terebratorium of miracidia and tegument of cercaria and schistosomula skin-stage. These findings suggest that SmFes may play a role in signal transduction pathways involved in larval transformation after penetration into intermediate and definitive hosts. (c) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Escola Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationFiocruz MS, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Glasgow, Div Infect & Immun, IBLS, Glasgow G12 8TA, Lanark, Scotland
dc.description.affiliationPrograma Pos Grad & Pequisa, Santa Casa Belo Horizonte, BR-30150221 Belo Horizonte, MG, Brazil
dc.description.affiliationEmbrapa Informat Agropecuria, Lab Bioinformat Estrutural, Campinas, SP, Brazil
dc.description.affiliationINSERM, U547, F-59045 Lille, France
dc.description.affiliationUniv Lille 2, Lille, France
dc.description.affiliationInst Pasteur, IFR 142, F-59019 Lille, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Escola Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent225-232
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2007.01.009
dc.identifier.citationExperimental Parasitology. San Diego: Academic Press Inc Elsevier Science, v. 116, n. 3, p. 225-232, 2007.
dc.identifier.doi10.1016/j.exppara.2007.01.009
dc.identifier.issn0014-4894
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29857
dc.identifier.wosWOS:000247662500005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofExperimental Parasitology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectprotein tyrosine kinaseen
dc.subjectimmunolocalizationen
dc.subjectShistosomaen
dc.subjecthost penetrationen
dc.titleSchistosonia mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetrationen
dc.typeinfo:eu-repo/semantics/article
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