Morphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic rats

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dc.contributor.authorMartins Pucci, Karla Roberta
dc.contributor.authorPereira Junior, Carlos Donizete
dc.contributor.authorIdalo, Priscila Barbosa
dc.contributor.authorSantana Pinheiro Moreira, Ana Carolina
dc.contributor.authorRocha, Laura Penna
dc.contributor.authorAquiles Rodrigues, Aldo Rogelis
dc.contributor.authorReis, Luiz Carlos dos
dc.contributor.authorSilva Gomes, Roseli A. da
dc.contributor.authorRocha, Lenaldo Branco
dc.contributor.authorOliveira Guimaraes, Camila Souza de
dc.contributor.authorReis, Marlene Antonia dos
dc.contributor.authorSaraiva Camara, Niels Olsen [UNIFESP]
dc.contributor.authorMiranda Correa, Rosana Rosa
dc.contributor.institutionUniv Fed Triangulo Mineiro
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:40:13Z
dc.date.available2016-01-24T14:40:13Z
dc.date.issued2015-03-01
dc.description.abstractObjective: To evaluate the effects of folic acid (FA)-induced renal failure in young offspring of diabetic mothers.Methods: the offspring of streptozotocin-induced diabetic dams were divided into four groups: CC (controls receiving vehicle); DC (diabetics receiving vehicle); CA (controls receiving FA solution, 250 mg/kg) and DA (diabetics receiving FA solution, 250 mg/kg). Renal function tests and morphometry results were analyzed.Results: An increase in creatinine and urea levels was observed in CA and DA groups at two and five months. FA administration caused a significant reduction in the number of glomeruli in the offspring of diabetic dams. the diabetes group treated with FA had fewer glomeruli compared to controls at two and five months. FA caused an increase in the area of the urinary space both in controls and offspring of diabetic dams at two and five months. the number of glomeruli and area of the urinary space at two months were negatively correlated.Conclusions: Fetal programing promotes remarkable changes in kidney morphology and function in offspring. We suggest that the morphological changes in the kidneys are more pronounced when fetal programing is associated with newly acquired diseases, e.g. renal failure induced by FA.en
dc.description.affiliationUniv Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Disciplina Patol Geral, BR-38025180 Uberaba, MG, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Discipline Physiol, Biol & Nat Sci Inst, BR-38025180 Uberaba, MG, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Discipline Biochem, Biol & Nat Sci Inst, BR-38025180 Uberaba, MG, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci 4, Dept Immunol, BR-09500900 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipFundacao de Ensino e Pesquisa de Uberaba (FUNEPU)
dc.format.extent403-408
dc.identifierhttp://dx.doi.org/10.3109/14767058.2014.918097
dc.identifier.citationJournal of Maternal-fetal & Neonatal Medicine. London: Informa Healthcare, v. 28, n. 4, p. 403-408, 2015.
dc.identifier.doi10.3109/14767058.2014.918097
dc.identifier.issn1476-7058
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38869
dc.identifier.wosWOS:000351133400006
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Maternal-fetal & Neonatal Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectDiabetesen
dc.subjectfolic acid-induced renal failureen
dc.subjectkidney morphologyen
dc.subjectmorphometryen
dc.subjectpregnancyen
dc.titleMorphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic ratsen
dc.typeinfo:eu-repo/semantics/article
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