Individual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in mice

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dc.contributor.authorSoeiro, Aline da Costa [UNIFESP]
dc.contributor.authorMoreira, Karin Di Monteiro [UNIFESP]
dc.contributor.authorAbrahao, Karina Possa [UNIFESP]
dc.contributor.authorHartmann Quadros, Isabel Marian [UNIFESP]
dc.contributor.authorMenezes Oliveira, Maria Gabriela [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:31Z
dc.date.available2016-01-24T14:27:31Z
dc.date.issued2012-08-01
dc.description.abstractModafinil is a non-amphetaminic psychostimulant used therapeutically for sleep and psychiatric disorders. However, some studies indicate that modafinil can have addictive properties. the present study examined whether modafinil can produce behavioral sensitization in mice, an experience and drug-dependent behavioral adaptation, and if individual differences play a role in this process. We further tested context-related factors and cross-sensitization between modafinil and methamphetamine. Important individual differences in the behavioral sensitization of Swiss Albino mice were observed after repeated administration of 50 mg/kg modafinil (Experiment 1), or 1 mg/kg methamphetamine (Experiment 2). Only mice classified as sensitized subgroup developed clear behavioral sensitization to the drugs. After a withdrawal period, mice received challenges of modafinil (Experiment 1), or methamphetamine (Experiment 2) and locomotor activity was evaluated in the activity cages (previous context) and in the open field arena (new context) in order to evaluate the context dependency of behavioral sensitization. the expression of sensitization to modafinil, but not to methamphetamine, was affected by contextual testing conditions, since modafinil-sensitized mice only expressed sensitization in the activity cage, but not in the open field. Subsequently, locomotor cross-sensitization between methamphetamine and modafinil was assessed by challenging modafinil-pretreated mice with 1 mg/kg methamphetamine (Experiment 1), and methamphetamine-pretreated mice with 50 mg/kg modafinil (Experiment 2). We observed a symmetrical cross-sensitization between the drugs only in those mice that were classified as sensitized subgroup. Our findings indicate that repeated exposure to modafinil induces behavioral sensitization only in some animals by similar neurobiological, but not contextual, mechanisms to those. of methamphetamine. (c) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent367-374
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2012.05.023
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 233, n. 2, p. 367-374, 2012.
dc.identifier.doi10.1016/j.bbr.2012.05.023
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35131
dc.identifier.wosWOS:000307368400017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectLocomotor sensitizationen
dc.subjectIndividual variabilityen
dc.subjectAmphetaminesen
dc.subjectDrugs of abuseen
dc.subjectLocomotor activityen
dc.subjectMiceen
dc.titleIndividual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in miceen
dc.typeinfo:eu-repo/semantics/article
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