Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats

Página do item simplificado
dc.contributor.authorSilva, Roberto Antoniolli da [UNIFESP]
dc.contributor.authorFagundes, Djalma José [UNIFESP]
dc.contributor.authorSilva, Andreia Conceicao Milan Brochado Antoniolli
dc.contributor.authorSisti, Karin Ellen
dc.contributor.authorCarvalho, Themis Maria Milan Brochado de
dc.contributor.authorSilva, Daniel Nunes e
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T11:14:55Z
dc.date.available2018-06-15T11:14:55Z
dc.date.issued2008-03-01
dc.description.abstractPurpose: To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Methods: Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Results: Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline Solution did not show statistically significant difference. Conclusions: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it.en
dc.description.affiliationFed Univ Mato Grosso do Sul UFMS, Dept Surg Clin, Mato Grosso, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Sch Med, Postgrad Program Surg & Experimentat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Sch Med, Postgrad Program Surg & Experimentat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent140-148
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502008000200006
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 140-148, 2008.
dc.identifier.doi10.1590/S0102-86502008000200006
dc.identifier.fileS0102-86502008000200006.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502008000200006
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/41976
dc.identifier.wosWOS:000258661800006
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbone transplantationen
dc.subjectanti-inflammatory agentsen
dc.subjectrats, wistaren
dc.titleEffect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in ratsen
dc.title.alternativeEfeito de antiinflamatórios na integração de enxerto ósseo autógeno e de matriz óssea bovina desvitalizada em ratospt
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos