Antimicrobial Susceptibility of Gram-Negative Bacilli Isolated in Brazilian Hospitals Participating in the SENTRY Program (2003-2008)

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dc.contributor.authorAndrade, Soraya Sgambatti [UNIFESP]
dc.contributor.authorSader, Helio Silva [UNIFESP]
dc.contributor.authorBarth, Afonso Luis
dc.contributor.authorRibeiro, Julival
dc.contributor.authorZoccoli, Cassia
dc.contributor.authorPignatari, Antonio Carlos Campos [UNIFESP]
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.institutionJMI Labs
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionHosp Base Dist Fed
dc.contributor.institutionLab Med Santa Luzia
dc.date.accessioned2018-06-15T14:04:34Z
dc.date.available2018-06-15T14:04:34Z
dc.date.issued2008-10-01
dc.description.abstractWe report the antimicrobial susceptibility patterns of the five most frequently isolated Gram-negative bacilli in the Brazilian hospitals participating in the SENTRY Program. A total of 3,220 Gram-negative bacilli were analyzed. The strains were consecutively collected (one per patient) between January 2003 and May 2008 and susceptibility tested by reference broth microdilution methods at the JMI Laboratories (North Liberty, Iowa, USA). The Gram-negative organisms most frequently isolated from bloodstream infections were Escherichia coli (12.8% of total), Klebsiella spp.(12.5%), Pseudomonas aeruginosa (9.6%), Acinetobacter spp. (8.0%) and Enterobacter spp. (6.4%). P aeruginosa ranked first (36.3% of cases) among organisms isolated from patients with pneumonia and second (15.1%) among organisms isolated from skin and soft tissue infections. Approximately 10% of E. coli and 50% of K. pneumoniae exhibited an ESBL phenotype. The carbapenems imipenem and meropenem were very active against Enterobacteriaceae strains, including E. coli and K. pneumoniae with ESBL phenotype and cefepime-non-susceptible Enterobacter spp., while ertapenem and polymyxin B showed more limited activity against Enterobacter spp. P. aeruginosa and Acinetobacter spp. showed high rates of resistance to all compounds tested except polymyxin B (99.4-99.9% susceptible). No antimicrobial agent alone provided appropriate coverage for the Gram-negative bacilli most frequently isolated in the hospitals participating in the SENTRY Program; thus, empiric therapy for serious infections may require a carbapenem (imipenem or meropenem) plus a polymyxin (polymyxin B or colistin).en
dc.description.affiliationJMI Labs, N Liberty, IA 52317 USA
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Base Dist Fed, Brasilia, DF, Brazil
dc.description.affiliationLab Med Santa Luzia, Florianopolis, SC, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent3-9
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Salvador: Contexto, v. 12, p. 3-9, 2008.
dc.identifier.issn1413-8670
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42884
dc.identifier.wosWOS:000266634000002
dc.language.isoeng
dc.publisherContexto
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsAcesso restrito
dc.subjectHospital-acquired infectionsen
dc.subjectSentry Programen
dc.subjectantimicrobial resistanceen
dc.subjectGram-negative bacillien
dc.titleAntimicrobial Susceptibility of Gram-Negative Bacilli Isolated in Brazilian Hospitals Participating in the SENTRY Program (2003-2008)en
dc.typeArtigo
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