Effects of in vitro, acute and chronic treatment with fluoxetine on the sympathetic neurotransmission of rat vas deferens

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dc.citation.volume203
dc.contributor.authorPedroso, Shaista Poppe [UNIFESP]
dc.contributor.authorde Souza, Bruno Palmieri [UNIFESP]
dc.contributor.authorJurkiewicz, Aron [UNIFESP]
dc.contributor.authorJuriewicz, Neide H. [UNIFESP]
dc.contributor.authorda Silva Junior, Edilson Dantas [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-17T14:02:48Z
dc.date.available2020-07-17T14:02:48Z
dc.date.issued2017
dc.description.abstractIt is described that fluoxetine treatment is able to induce ejaculatory disorders. However, the exact mechanism is still not fully understood. Therefore, this study was carried out to further evaluate the anti-ejaculatory effects of fluoxetine, using different approaches (in vitro or in vivo treatments), on the sympathetic neurotransmission of the rat vas deferens. Vas deferens from male Wistar rats were used to check the in vitro effects of fluoxetine 10(-6) M, 3.10(-6) M or 10(-5) M. Animals were also acutely (20 mg/kg, i.p. 4 h or 24 h) or chronically (10 mg/kg, i.p., 30 days) treated with fluoxetine or drug-free vehicle. The vas deferens from non -treated and treated animals were isolated and mounted in an isolated organ bath for the study of the contractions induced by adrenergic agonists, tyramine, 5-HT, Ca2+ or electrical field stimulation. In vitro or acute treatment with fluoxetine decreased the contraction induced by agonists, Ca2+ or electrical field stimulation. The chronic treatment with fluoxetine decreased the contractions induced agonists, tyramine or Ca2+, but did not modify the contractions induced by electrical field stimulation. We have shown that in vitro or in vivo fluoxetine treatment is able to alter the sympathetic neurotransmission of the rat vas deferens which could be related to alterations in the calcium signalling. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq
dc.format.extent17-24
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2016.10.006
dc.identifier.citationAutonomic Neuroscience-Basic & Clinical. Amsterdam, v. 203, p. 17-24, 2017.
dc.identifier.doi10.1016/j.autneu.2016.10.006
dc.identifier.issn1566-0702
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55037
dc.identifier.wosWOS:000397358100003
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofAutonomic Neuroscience-Basic & Clinical
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFluoxetineen
dc.subjectVas deferensen
dc.subjectSympathetic neurotransmissionen
dc.subjectIn vitro or in vivo treatmentsen
dc.titleEffects of in vitro, acute and chronic treatment with fluoxetine on the sympathetic neurotransmission of rat vas deferensen
dc.typeinfo:eu-repo/semantics/article
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