The action of prolyl-leucyl-glycinamide (PLG) on the nigrostriatal pathway of the rat

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dc.contributor.authorPereira, João S.
dc.contributor.authorAndrade, Luiz Augusto Franco de [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorLima, J. Geraldo Camargo [UNIFESP]
dc.contributor.authorFerraz, Henrique B.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:24:19Z
dc.date.available2015-06-14T13:24:19Z
dc.date.issued1990-06-01
dc.description.abstractIn order to study the nigrostriatal pathway, we obtained the rotatory behavior model in male Wistar rats by electrolytic lesion of the left lateral hypothalamic region. Animals thus lesioned displayed rotations toward the same side of lesion when apomorphine was administered, a result in disagreement with what has been obtained in the model with 6-hydroxydopamine lesion. The administration of PLG alone was not followed by rotatory behavior but when the compound was administered in low doses (0.25 to 1mg/kg) simultaneously with apomorphine to animals previously submitted to REM sleep deprivation, a significant increase in the number of rotations was observed in comparison with controls and groups receiving higher doses of PLG. These results indicate that PLG may act as, a modulator on dopamine receptors in the striatum.en
dc.description.abstractNo intuito de estudar a via nigroestriatal, produzimos uma lesão na região hipotalâmica lateral de ratos Wistar. Os animais passavam a apresentar comportamento rotatório para o mesmo lado da lesão. A administração isolada do PLG não induziu o comportamento rotatório. Entretanto, com doses baixas do composto, concomitantemente à administração de apomorfina em animais previamente submetidos à privação de sono REM, observou-se aumento no número de rotações auando comparado ao grupo controle e aos grupos aue receberam doses altas de PLG. Estes achados sugerem que o PLG age como um modulador sobre os receptores dopaminérgicos do estriado.pt
dc.description.affiliationEscola Paulista de Medicina Department of Neurology and Neurosurgery Division of Extrapyramidal Diseases Investigation
dc.description.affiliationEscola Paulista de Medicina Department of Neurology and Neurosurgery Head of the Division - Division of Extrapyramidal Diseases Investigation
dc.description.affiliationUnifespUNIFESP, EPM, Department of Neurology and Neurosurgery Division of Extrapyramidal Diseases Investigation
dc.description.affiliationUnifespEscola Paulista de Medicina Department of Neurology and Neurosurgery Head of the Division - Division of Extrapyramidal Diseases Investigation
dc.description.sourceSciELO
dc.format.extent156-160
dc.identifierhttp://dx.doi.org/10.1590/S0004-282X1990000200002
dc.identifier.citationArquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 48, n. 2, p. 156-160, 1990.
dc.identifier.doi10.1590/S0004-282X1990000200002
dc.identifier.fileS0004-282X1990000200002.pdf
dc.identifier.issn0004-282X
dc.identifier.scieloS0004-282X1990000200002
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/255
dc.language.isoeng
dc.publisherAcademia Brasileira de Neurologia - ABNEURO
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe action of prolyl-leucyl-glycinamide (PLG) on the nigrostriatal pathway of the raten
dc.title.alternativeAção de prolil-leucil-gliclnamida (PLG) na via nigroestriatal do ratopt
dc.typeinfo:eu-repo/semantics/article
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