Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Página do item simplificado
dc.contributor.authorMaragno-Correa, Jussara Maria Ragonezzi [UNIFESP]
dc.contributor.authorPatti, Camilla L. [UNIFESP]
dc.contributor.authorZanin, Karina A. [UNIFESP]
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorRuiz, Francieli S. [UNIFESP]
dc.contributor.authorZager, Adriano
dc.contributor.authorSa-Nunes, Anderson
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:31:06Z
dc.date.available2016-01-24T14:31:06Z
dc.date.issued2013-01-01
dc.description.abstractObjectives:Sleep deprivation is a growing public health hazard, yet it is still under-recognized. Sleep disorders and disruption of sleep patterns may compromise the immune function and adversely affect host resistance to infectious diseases. This is a particular risk in cancer patients, who report a high frequency of sleep disturbances. the present study investigated the effects of sleep deprivation on the development of Ehrlich ascitic tumors (EAT) in female BALB/c mice. Our study also evaluated whether EAT would induce alterations in sleep pattern. Spleen lymphocyte cell populations and mortality were also quantified. Methods: Female BALB/c mice were intraperitoneally inoculated with EAT cells. Immediately after the inoculation procedure, animals were sleep deprived for 72 h. Ten or 15 days after inoculation, the number of tumoral cells was quantified and the lymphocytic cell population in the spleen was characterized by flow cytometry. in addition, the effect of sleep deprivation on EAT-induced mortality was quantified and the influence of EAT on sleep patterns was determined. Results: Sleep deprivation did not potentiate EAT growth, but it significantly increased mortality. Additionally, both EAT and sleep deprivation decreased frequencies of splenic CD4+, CD8+ and CD19+ cells. With respect to sleep patterns, EAT significantly enhanced paradoxical sleep time. Conclusions: Although sleep deprivation did not potentiate EAT growth, it decreased the survival of female tumor-bearing mice. Copyright (c) 2013 S. Karger AG, Baselen
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecnia, Dept Patol, Grp Neuroimunomodulacao, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Imunol Expt, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent134-140
dc.identifierhttp://dx.doi.org/10.1159/000346201
dc.identifier.citationNeuroimmunomodulation. Basel: Karger, v. 20, n. 3, p. 134-140, 2013.
dc.identifier.doi10.1159/000346201
dc.identifier.issn1021-7401
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35845
dc.identifier.wosWOS:000318463600002
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofNeuroimmunomodulation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectEhrlich ascitic tumoren
dc.subjectSleep restrictionen
dc.subjectImmune systemen
dc.subjectParadoxical sleepen
dc.titleSleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumoren
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos