Minimization of transcriptional temporal noise and scale invariance in the yeast genome

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dc.contributor.authorFerreira, R. C. [UNIFESP]
dc.contributor.authorBosco, Francisco [UNIFESP]
dc.contributor.authorPaiva, Paulo Bandiera [UNIFESP]
dc.contributor.authorBriones, Marcelo Ribeiro da Silva [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:30:20Z
dc.date.available2018-06-15T17:30:20Z
dc.date.issued2007-01-01
dc.description.abstractThe analysis of transcriptional temporal noise could be an interesting means to study gene expression dynamics and stochasticity in eukaryotes. To study the statistical distributions of temporal noise in the eukaryotic model system Saccharomyces cerevisiae, we analyzed microarray data corresponding to one cell cycle for 6200 genes. We found that the temporal noise follows a lognormal distribution with scale invariance at the genome, chromosomal and sub-chromosomal levels. Correlation of temporal noise with the codon adaptation index suggests that at least 70% of all protein-coding genes are a noise minimization core of the genome. Accordingly, a mathematical model of individual gene expression dynamics was proposed, using an operator theoretical approach, which reveals strict conditions for noise variability and a possible global noise minimization/optimization strategy at the genome level. Our model and data show that minimal noise does not correspond to genes obeying a strictly deterministic dynamics. The natural strategy of minimization consists in equating the mean of the absolute value of the relative variation of the expression level (alpha) with noise (eta). We hypothesize that the temporal noise pattern is an emergent property of the genome and shows how the dynamics of gene expression could be related to chromosomal organization.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Informat Saude, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Informat Saude, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent397-414
dc.identifierhttp://www.funpecrp.com.br/gmr/year2007/vol2-6/gmr0318_abstract.htm
dc.identifier.citationGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 6, n. 2, p. 397-414, 2007.
dc.identifier.fileWOS000251696400018.pdf
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43718
dc.identifier.wosWOS:000251696400018
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecttranscriptionen
dc.subjectnoiseen
dc.subjectscale invarianceen
dc.subjectyeast genomeen
dc.titleMinimization of transcriptional temporal noise and scale invariance in the yeast genomeen
dc.typeinfo:eu-repo/semantics/article
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