Overexpression of the ITGAV Gene Is Associated with Progression and Spread of Colorectal Cancer

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dc.contributor.authorWaisberg, Jaques [UNIFESP]
dc.contributor.authorViana, Luciano de Souza [UNIFESP]
dc.contributor.authorAffonso Junior, Renato Jose [UNIFESP]
dc.contributor.authorSilva, Sandra Regina Morini da [UNIFESP]
dc.contributor.authorDenadai, Marcos Vinicius Araujo [UNIFESP]
dc.contributor.authorMargeotto, Fernando Beani
dc.contributor.authorSouza, Carolina Salinas de [UNIFESP]
dc.contributor.authorMatos, Delcio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBarretos Canc Hosp
dc.contributor.institutionABC Med Sch
dc.date.accessioned2018-06-15T13:50:15Z
dc.date.available2018-06-15T13:50:15Z
dc.date.issued2014-10-01
dc.description.abstractBackground/ Aim: The interaction of neoplastic cells with the extracellular matrix is a critical event for the initiation of cancer invasion and metastasis. We evaluated the relationship between the expression of SPARC, ITGAV, THBS1 and VCAM-1 genes of extracellular matrix in the progression and dissemination of colorectal cancer (CRC). Patients and Methods: Adult patients (N=114) underwent resection of CRC. Gene expression in CRC was determined by quantitative real-time polymerase chain reaction (PCR). Protein expression was analyzed by immunohistochemistry (IHC). Correlation with pathway-related molecules (p53, Bcl-2, Ki-67, EGFR and VEGF) was assessed. Results: Tumors with perineural invasion showed overexpression (p=0.028) of the ITGAV gene with regard to cancers without perineural invasion and validation of the result through IHC expression of the corresponding proteins, was significant for the expression of ITGAV protein (p=0.001). Conclusion: The overexpression of ITGAV gene was associated with higher progression and spread of CRC via perineural invasion.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationBarretos Canc Hosp, Dept Oncol, Sao Paulo, Brazil
dc.description.affiliationBarretos Canc Hosp, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationABC Med Sch, Dept Surg, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Genet Lab GRAACC, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Genet Lab GRAACC, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent5599-5607
dc.identifierhttp://ar.iiarjournals.org/content/34/10/5599.abstract
dc.identifier.citationAnticancer Research. Athens: Int Inst Anticancer Research, v. 34, n. 10, p. 5599-5607, 2014.
dc.identifier.issn0250-7005
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42600
dc.identifier.wosWOS:000343139500048
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofAnticancer Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBiological markersen
dc.subjectcolorectal neoplasmsen
dc.subjectextracellular matrixen
dc.subjectgene expressionen
dc.subjecttumor markersen
dc.titleOverexpression of the ITGAV Gene Is Associated with Progression and Spread of Colorectal Canceren
dc.typeinfo:eu-repo/semantics/article
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