Genetic Analysis of Lrp5 Function in Osteoblast Progenitors

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dc.contributor.authorYadav, Vijay K.
dc.contributor.authorArantes, Henrique Pierotti [UNIFESP]
dc.contributor.authorBarros, Elizabete Ribeiro [UNIFESP]
dc.contributor.authorLazaretti-Castro, Marise [UNIFESP]
dc.contributor.authorDucy, Patricia
dc.contributor.institutionColumbia Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:38Z
dc.date.available2016-01-24T13:59:38Z
dc.date.issued2010-05-01
dc.description.abstractThe low-density lipoprotein receptor-related protein (Lrp)-5 regulates osteoblast proliferation and bone formation through its expression in duodenum by modifying the gut serotonin-bone endocrine axis. However, its direct role, if any, in osteoblast progenitor cells has not been studied thus far. Here, we show that mice with a Dermo1-Cre-mediated disruption of Lrp5 in osteoblast progenitor cells have normal embryonic skeletogenesis and normal skeletal growth and development postnatally. Histomorphometric analysis of 3-month-old adult mice revealed normal osteoblast numbers, bone formation rate, and bone mass in Lrp5 (Dermo) (-/-) mice. in addition, analysis of two osteoporosis pseudoglioma (OPPG) patients revealed a three- to fivefold increase in their serum serotonin levels compared to age-matched controls. These results rule out a direct function of Lrp5 in osteoblast progenitor cells and add further support to the notion that dysregulation of serotonin synthesis is involved in bone mass abnormalities observed in OPPG patients.en
dc.description.affiliationColumbia Univ, Med Ctr, Dept Pathol, New York, NY 10032 USA
dc.description.affiliationColumbia Univ, Med Ctr, Dept Genet & Dev, New York, NY 10032 USA
dc.description.affiliationUniversidade Federal de São Paulo, Div Endocrinol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Bone & Mineral Unit, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Endocrinol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Bone & Mineral Unit, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNIH
dc.description.sponsorshipIBMS
dc.format.extent382-388
dc.identifierhttp://dx.doi.org/10.1007/s00223-010-9350-7
dc.identifier.citationCalcified Tissue International. New York: Springer, v. 86, n. 5, p. 382-388, 2010.
dc.identifier.doi10.1007/s00223-010-9350-7
dc.identifier.issn0171-967X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32501
dc.identifier.wosWOS:000277014000007
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCalcified Tissue International
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectOsteoblasten
dc.subjectOsteoporosisen
dc.subjectAnimal modelen
dc.subjectMouse genetics/transgenicsen
dc.titleGenetic Analysis of Lrp5 Function in Osteoblast Progenitorsen
dc.typeinfo:eu-repo/semantics/article
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