Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates

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dc.citation.volume8
dc.contributor.authorTravassos, Luiz R. [UNIFESP]
dc.contributor.authorTaborda, Carlos P. [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-17T14:02:39Z
dc.date.available2020-07-17T14:02:39Z
dc.date.issued2017
dc.description.abstractDimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South Americaen
dc.description.abstractHistoplasma capsulatum, Coccidioides posadasii, and Coccidioides immitis, and the Sporothrix spp. complex are other important pathogens. Associated with dimorphic fungi other important infections are caused by yeast such as Candida spp. and Cryptococcus spp. or mold such as Aspergillus spp., which are also fungal agents of deadly infections. Nowadays, the actual tendency of therapy is the development of a pan-fungal vaccine. This is, however, not easy because of the complexity of eukaryotic cells and the particularities of different species and isolates. Albeit there are several experimental vaccines being studied, we will focus mainly on peptide vaccines or epitopes of T-cell receptors inducing protective fungal responses. These peptides can be carried by antibody inducing beta-( 1,3)-glucan oligo or polysaccharides, or be mixed with them for administration. The present review discusses the efficacy of linear peptide epitopes in the context of antifungal immunization and vaccine proposition.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-17T14:02:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2017. Added 1 bitstream(s) on 2020-07-17T14:35:41Z : No. of bitstreams: 1 WOS000395863200001.pdf: 724433 bytes, checksum: fdc8dd891e55eb6552b956f0f2becfe0 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCAPES
dc.description.sponsorshipIDFAPESP: 2016/08730-6
dc.description.sponsorshipIDFAPESP: 2010/51423-0
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2017.00224
dc.identifier.citationFrontiers In Immunology. Lausanne, v. 8, p. -, 2017.
dc.identifier.doi10.3389/fimmu.2017.00224
dc.identifier.fileWOS000395863200001.pdf
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54931
dc.identifier.wosWOS:000395863200001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Immunology
dc.rightsAcesso aberto
dc.subjectpeptideen
dc.subjectvaccineen
dc.subjectantibodyen
dc.subjectfungien
dc.subjectParacoccidioidesen
dc.titleLinear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidatesen
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