LOSS of STRIATAL HIGH-AFFINITY NGF BINDING-SITES in PROGRESSIVE SUPRANUCLEAR PALSY BUT NOT in PARKINSONS-DISEASE

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dc.contributor.authorVillares, J.
dc.contributor.authorStrada, O.
dc.contributor.authorFaucheux, B.
dc.contributor.authorJavoyagid, F.
dc.contributor.authorAgid, Y.
dc.contributor.authorHirsch, E. C.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:21Z
dc.date.available2016-01-24T11:40:21Z
dc.date.issued1994-11-21
dc.description.abstractI-125-Nerve growth factor (NGF) binding sites were analyzed by autoradiography in the striatum of 3 central subjects, 3 patients with Parkinson's disease and 3 patients with progressive supranuclear palsy. A high level of I-125-NGF binding was observed (0.3-0.4 fmol/mg of tissue equivalent) in the striatum and the nucleus basalis of Meynert of control patients. Pockets of lower I-125-NGF binding corresponding to acetylcholinesterase-poor striosomes were detected in the striatum of control subjects and patients with Parkinson's disease or progressive supranuclear palsy. When compared to controls, the density of I-125-NGF binding sites was reduced by 30% in the striatum of patients with progressive supranuclear palsy but not reduced in that of patients with Parkinson's disease. I-125-NGF binding was not significantly decreased in the nucleus basalis of Meynert in either diseases. Since NGF receptors are thought to be localized on cholinergic neurons in the striatum, the decrease in NGF binding is compatible with the loss of cholinergic neurons reported in the striatum from PSP patients.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT PSYCHOBIOL,São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PSYCHOBIOL,São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent59-62
dc.identifierhttp://dx.doi.org/10.1016/0304-3940(94)90205-4
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Sci Publ Ireland Ltd, v. 182, n. 1, p. 59-62, 1994.
dc.identifier.doi10.1016/0304-3940(94)90205-4
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25447
dc.identifier.wosWOS:A1994PY09300016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCHOLINERGIC NEURONen
dc.subjectNERVE GROWTH FACTORen
dc.subjectPARKINSONS DISEASEen
dc.subjectPROGRESSIVE SUPRANUCLEAR PALSYen
dc.subjectAUTORADIOGRAPHYen
dc.titleLOSS of STRIATAL HIGH-AFFINITY NGF BINDING-SITES in PROGRESSIVE SUPRANUCLEAR PALSY BUT NOT in PARKINSONS-DISEASEen
dc.typeinfo:eu-repo/semantics/article
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