Igf-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea

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dc.contributor.authorIzumi, Suelem [UNIFESP]
dc.contributor.authorRibeiro-Filho, Fernando F.
dc.contributor.authorCarneiro, Glaucia [UNIFESP]
dc.contributor.authorTogeiro, Sania M. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorZanella, Maria T. [UNIFESP]
dc.date.accessioned2019-01-21T10:30:01Z
dc.date.available2019-01-21T10:30:01Z
dc.date.issued2016
dc.description.abstractStudy Objectives: This study examined insulin-like growth factor-1 (IGF-1) production and its association with the metabolic syndrome (MS) in men with obstructive sleep apnea (OSA). Methods: In total, 47 overweight and obese men who had been referred for suspected OSA underwent polysomnography and were classified based on the apnea-hypopnea index (AHI) into three groups: no OSA, < 5 events/h (n = 11)en
dc.description.abstractmild OSA, >= 5 to < 15 events/h (n = 8)en
dc.description.abstractand moderate-severe OSA, >= 15 events/h (n = 28). The assessment of the somatotropic axis function included IGF-1 measurement. MS was diagnosed according to the National Cholesterol Education Program guidelines. Results: IGF-1 level in the moderate-severe OSA group was lower than in the no-OSA group (156.8 +/- 54.3 mu g/L versus 225.5 +/- 80.5 mu g/Len
dc.description.abstractp = 0.013). IGF-1 level was negatively correlated with body mass index, waist circumference (WC), AHI, and sleep duration with oxygen (O-2) saturation < 90% and positively correlated with the average and minimum O-2 saturation (p = 0.027). In a multivariable linear regression, considering WC and minimum O-2 saturation as independent variables, only the minimum O-2 saturation was a predictor of low IGF-1 levels. The proportions of patients with MS were different between the three groups (18.2% in no OSAen
dc.description.abstract25% in mild OSA, and 57.1% in moderate-severe OSAen
dc.description.abstractp = 0.047). Furthermore, in the lowest tertile of IGF-1 value, 66.7% of patients were affected by MS (p = 0.049). Hemoglobin (Hb)A1c correlated negatively with the minimum O-2 saturation and IGF-1 levels. However, in multivariable linear regression only IGF-1 levels were a predictor of HbA1c levels. Conclusion: The occurrence of OSA is associated with a reduction in IGF-1 levels. IGF-1 alterations in OSA also seem to be associated with a higher prevalence of MS.en
dc.description.affiliationDepartment of Endocrinology, Universidade Federal de São Paulo, SP, Brazil
dc.description.affiliationDepartment of Endocrinology, Universidade Federal do Pará, PA, Brazil
dc.description.affiliationDepartment of Psycobiology, Sleep Disorders Center, Universidade Federal de São Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Endocrinology, Universidade Federal de São Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Psycobiology, Sleep Disorders Center, Universidade Federal de São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Pesquisa (CNPq)
dc.description.sponsorshipAFIP (Associacao Fundo de Incentivo a Pesquisa)
dc.format.extent487-493
dc.identifierhttp://dx.doi.org/10.5664/jcsm.5672
dc.identifier.citationJournal Of Clinical Sleep Medicine. Westchester, v. 12, n. 4, p. 487-493, 2016.
dc.identifier.doi10.5664/jcsm.5672
dc.identifier.issn1550-9389
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49538
dc.identifier.wosWOS:000374140000005
dc.language.isoeng
dc.publisherAmer acad sleep medicine
dc.relation.ispartofJournal Of Clinical Sleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectGh/Igf-1 Axisen
dc.subjectIgf-1en
dc.subjectInsulin-Like Growth Factor-1en
dc.subjectMetabolic Syndromeen
dc.subjectObstructive Sleep ApneaGrowth-Factor-Ien
dc.subjectOnset Gh Deficiencyen
dc.subjectHypopituitary Patientsen
dc.subjectGeneral-Populationen
dc.subjectInsulin-Resistanceen
dc.subjectHormone Secretionen
dc.subjectObese-Patientsen
dc.subjectKims Analysisen
dc.subjectPrevalenceen
dc.subjectAdultsen
dc.titleIgf-1 levels are inversely associated with metabolic syndrome in obstructive sleep apneaen
dc.typeinfo:eu-repo/semantics/article
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