Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae

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dc.contributor.authorNogueira, Keite da Silva
dc.contributor.authorDaur, Alessandra Vale
dc.contributor.authorReason, Iara Taborda de Messias
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.authorCosta, Libera Maria Dalla
dc.contributor.institutionUniversidade Federal do Paraná Hospital de Clínicas
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:43:02Z
dc.date.available2015-06-14T13:43:02Z
dc.date.issued2011-04-01
dc.description.abstractThe objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone > 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.en
dc.description.affiliationUniversidade Federal do Paraná Hospital de Clínicas
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Laboratório Alerta
dc.description.affiliationUnifespUNIFESP, Laboratório Alerta
dc.description.sourceSciELO
dc.format.extent167-169
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702011000200014
dc.identifier.citationBrazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 2, p. 167-169, 2011.
dc.identifier.doi10.1590/S1413-86702011000200014
dc.identifier.fileS1413-86702011000200014.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702011000200014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6417
dc.identifier.wosWOS:000289645600014
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseases
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectenterobacteriaceaeen
dc.subjectbeta-lactamasesen
dc.subjectcephalosporin resistanceen
dc.titleCefepime versus extended spectrum β-lactamase-producing Enterobacteriaceaeen
dc.typeinfo:eu-repo/semantics/article
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