Comparison between subjective feelings to alcohol and nitrogen narcosis: A pilot study

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dc.contributor.authorMonteiro, M. G.
dc.contributor.authorHernandez, W.
dc.contributor.authorFiglie, N. B.
dc.contributor.authorTakahashi, E.
dc.contributor.authorKorukian, M.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:28Z
dc.date.available2016-01-24T11:40:28Z
dc.date.issued1996-01-01
dc.description.abstractNitrogen narcosis is often compared to alcohol intoxication, but no actual studies have been carried out in humans to test the comparability of these effects. If a common mechanism of action is responsible for the behavioral effects of these substances, biological variability of response to alcohol should correlate to that of nitrogen in the same individual. To test this hypothesis, subjective feelings were assessed in two separate occasions in 14 adult male, healthy volunteers, nonprofessional divers. in one occasion, each subject received 0.75 ml/kg (0.60 g/kg) alcohol 50% (v/v PO) and in another day underwent a simulated dive at 50 m for 30 min in a hyperbaric chamber. There was a significant correlation between reported feelings in the two sessions; subjects who felt less intoxicated after drinking also felt less nitrogen narcosis during the simulated dive. the results, although preliminary, raise the hypothesis that ethanol and nitrogen may share the same mechanisms of action in the brain and that biological differences might account for interindividual variability of responses to both ethanol and nitrogen.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT PSYCHOBIOL,RUA BOTUCATU 862,1 ANDAR,BR-04023062 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PSYCHOBIOL,RUA BOTUCATU 862,1 ANDAR,BR-04023062 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent75-78
dc.identifierhttp://dx.doi.org/10.1016/0741-8329(95)02016-0
dc.identifier.citationAlcohol. Oxford: Pergamon-Elsevier B.V., v. 13, n. 1, p. 75-78, 1996.
dc.identifier.doi10.1016/0741-8329(95)02016-0
dc.identifier.issn0741-8329
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25551
dc.identifier.wosWOS:A1996TW35000015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAlcohol
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectethanolen
dc.subjectnitrogen narcosisen
dc.subjectgenetic differencesen
dc.subjectintoxicationen
dc.subjecthyperbaric environmenten
dc.titleComparison between subjective feelings to alcohol and nitrogen narcosis: A pilot studyen
dc.typeinfo:eu-repo/semantics/article
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