Antimicrobial activity of tigecycline against community-acquired methicillin-resistant Staphylococcus aureus isolates recovered from North American medical centers

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dc.contributor.authorMendes, Rodrigo Elisandro
dc.contributor.authorSader, Helio Silva [UNIFESP]
dc.contributor.authorDeshpande, Lalitagauri
dc.contributor.authorJones, Ronald N.
dc.contributor.institutionJMI Labs
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTufts Univ
dc.date.accessioned2016-01-24T13:49:42Z
dc.date.available2016-01-24T13:49:42Z
dc.date.issued2008-04-01
dc.description.abstractA total of 1989 community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) were susceptibility tested by broth microdilution. Pulsed-field gel electrophoresis, SCCmec type, and polymerase chain reaction for Panton-Valentine leukocidin (PVL) genes were also performed. the overall tigecycline susceptibility rate was 98.2%. Glycopeptides, quinupristin/dalfopristin, linezolid, and chloramphenicol were also active against this collection (<= 0.7% resistant). the vast majority (70.8%) of the CA-MRSA was SCCmec type IV, from which 88.4% belonged to the USA300-0114 clone and 94.7% were PVL positive. Tigecycline showed in vitro activity comparable with other highly active parenteral agents and represents an option for treating complicated infections caused by CA-MRSA. (C) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationJMI Labs, N Liberty, IA 52317 USA
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, BR-04023900 São Paulo, Brazil
dc.description.affiliationTufts Univ, Sch Med, Boston, MA 02111 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent433-436
dc.identifierhttps://dx.doi.org/10.1016/j.diagmicrobio.2007.10.016
dc.identifier.citationDiagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 60, n. 4, p. 433-436, 2008.
dc.identifier.doi10.1016/j.diagmicrobio.2007.10.016
dc.identifier.issn0732-8893
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30559
dc.identifier.wosWOS:000254565300018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectTigecyclineen
dc.subjectCommunity-acquired methicillin-resistant S. aureusen
dc.subjectCA-MRSAen
dc.subjectcSSTIen
dc.titleAntimicrobial activity of tigecycline against community-acquired methicillin-resistant Staphylococcus aureus isolates recovered from North American medical centersen
dc.typeinfo:eu-repo/semantics/article
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