Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1

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dc.citation.issue3
dc.citation.volume31
dc.contributor.authorSagica Fernandes Paschoal, Joelma Karin [UNIFESP]
dc.contributor.authorPaschoal, Fernando Mendes, Jr.
dc.contributor.authorde Lima, Fernanda Teresa [UNIFESP]
dc.contributor.authorPinho, Ricardo Silva [UNIFESP]
dc.contributor.authorPereira Vilanova, Luiz Celso [UNIFESP]
dc.contributor.authorBor-Seng-Shu, Edson
dc.contributor.authorMasruha, Marcelo Rodrigues [UNIFESP]
dc.coverageThousand Oaks
dc.date.accessioned2020-08-21T17:00:18Z
dc.date.available2020-08-21T17:00:18Z
dc.date.issued2016
dc.description.abstractNeurofibromatosis type 1 is characterized by nerve sheath neurofibromas associated with a number of additional clinical features, including cerebrovascular disease. The aim of this study was to use transcranial Doppler as a screening method for identifying cerebral vasculopathy in children with neurofibromatosis type 1. Forty children with neurofibromatosis type 1, aged 5 to 18 years old, were examined by transcranial Doppler. Patients presenting with hemodynamic features of arterial stenosis/occlusion on transcranial Doppler underwent magnetic resonance angiography to confirm the findings. Magnetic resonance angiography was performed on 4 children who exhibited a transcranial Doppler hemodynamic pattern indicative of cerebral vasculopathy. Among these cases, 2 presented internal carotid artery stenosis/occlusion, 1 had bilateral middle cerebral artery stenosis, and 1 presented a normal magnetic resonance angiography result. Transcranial Doppler can be used routinely in the investigation of cerebrovascular disease in neurofibromatosis type 1 patients, where magnetic resonance angiography can be subsequently applied to confirm the diagnosis, further contributing to the prevention of cerebrovascular events.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Hosp Clin,Div Clin Neurosurg, Lab Neurosonol & Cerebral Hemodynam, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent351-356
dc.identifierhttp://dx.doi.org/10.1177/0883073815595080
dc.identifier.citationJournal Of Child Neurology. Thousand Oaks, v. 31, n. 3, p. 351-356, 2016.
dc.identifier.doi10.1177/0883073815595080
dc.identifier.issn0883-0738
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57931
dc.identifier.wosWOS:000370429700013
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal Of Child Neurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjecttranscranial Doppleren
dc.subjectneurofibromatosisen
dc.subjectcerebrovascular diseaseen
dc.titleDetection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1en
dc.typeinfo:eu-repo/semantics/article
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